DEFICITS IN DRINKING AND VASOPRESSIN SECRETION AFTER LESIONS OF THE NUCLEUS MEDIANUS
DEFICITS IN DRINKING AND VASOPRESSIN SECRETION AFTER LESIONS OF THE NUCLEUS MEDIANUS
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DOI：
10.1159/000123518
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发表时间：
1983-01-01
影响因子：
4.1
通讯作者：
GANONG, WF
中科院分区：
文献类型：
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作者：
MANGIAPANE, ML;THRASHER, TN;GANONG, WF
在雄性 Long-Evans 大鼠中研究了消融正中核对饮酒和加压素分泌的影响。皮下注射后评估 1 小时内的饮水量。注射 5.8% NaCl (13.34 mosm/kg) 或血管紧张素 II (1.5 mg/kg)。在没有水的单独测试中，在上述剂量的高渗盐水后 15 分钟测量血浆加压素。消融正中核或正中核的背侧和前部，阻止饮用高渗盐水或血管紧张素 II，并减弱加压素对高渗透压的反应。具有间隔或对角线带损伤的动物表现出与假手术大鼠相当的反应。对液体平衡很重要的神经通路显然穿过或终止于正中核。
The effects of ablation of the nucleus medianus on drinking and vasopressin secretion were studied in male Long-Evans rats. The amount of water drunk in 1 h was assessed after s.c. injection of 5.8% NaCl (13.34 mosm/kg) or of angiotensin II (1.5 mg/kg). In a separate test with no water available, plasma vasopressin was measured 15 min after the above dose hypertonic saline. Ablation of the nucleus medianus, or the dorsal and anterior portions of the nucleus medianus, blocked drinking to hypertonic saline or angiotensin II, and attenuated the vasopressin response to hyperosmolality. Animals with septal or diagonal band lesions showed responses comparable to sham-operated rats. A neural pathway important for fluid balance apparently passes through, or terminates in, the nucleus medianus.