Plasmodium cell biology should inform strategies used in the development of antimalarial transmission-blocking drugs
Plasmodium cell biology should inform strategies used in the development of antimalarial transmission-blocking drugs
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DOI：
10.4155/fmc.12.182
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发表时间：
2012-12-01
影响因子：
4.2
通讯作者：
Delves, Michael J.
中科院分区：
文献类型：
--
作者：
Delves, Michael J.
疟疾是一种具有破坏性影响的疾病，每年影响2.16亿人，造成655 000人死亡，其中大多数是5岁以下儿童。最近认识到，根除疟疾需要新的干预措施，以针对寄生虫从人类宿主传播到蚊子的过程中，导致开发传播阻断药物和高通量检测方法的活动激增。本文概述了传输阶段的细胞生物学，并讨论了其对检测开发的影响，为研究人员提供了一个背景，以评估从目前的检测和考虑未来的检测设计获得的筛选数据的相对优点/缺点。最新的知识，目前的抗疟类的传播阻断性能也进行了总结，并强调了不发达的目标，传播阶段的药物发现。
Malaria is a disease with a devastating impact affecting 216 million people each year and causing 655,000 deaths, most of which are children under 5 years old. Recent appreciation that malaria eradication will require novel interventions to target the parasite during transmission from the human host to the mosquito has lead to an exciting surge in activity to develop transmission-blocking drugs and the high-throughput assays to screen for them. This article presents an overview of transmission-stage cell biology and discusses its impact on assay development to provide a context for researchers to evaluate the relative merits/drawbacks of both screening data obtained from current assays and considerations for future assay design. The most recent knowledge of the transmission-blocking properties of current antimalarial classes is also summarized and, underdeveloped targets for transmission-stage drug discovery are highlighted.