Stem Cell Engineering - Principles and Applications
Stem Cell Engineering - Principles and Applications
复制标题
干细胞工程 - 原理与应用
DOI：
10.1007/978-3-642-11865-4_11
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Dalby M
中科院分区：
文献类型：
--
作者：
Dalby M
细胞对其环境的形状做出强烈反应，这称为接触引导。多年来，这一直是微观尺度和终末分化细胞类型的研究。随着材料技术的发展，纳米尺度的研究现在已经成为可能。与这些进步同步的是干细胞培养的发展。这篇综述着眼于成体干细胞/纳米级界面，考虑细胞粘附、运动、基因表达（机械转导）和最终分化。特别令人感兴趣的是界面核的重组以及可能与分化的联系。
Cells respond strongly to the shape of their environment and this is called contact guidence. For many years this has been studies at the microscale and with terminally differentiated cell types. With developments in materials technology studies at the nanoscale are now possible. Hand-in hand with these advances are developments in stem cell culture. This review looks at the adult stem cell/nanoscale interface considering cell adhesion, motility, gene expression (mechanotransduction) and ultimately differentiation. Particularly of interest is the reorganisation of the interface nucleus and possible links to differentiation.