Metabolomic biomarkers as strong correlates of Parkinson disease progression
Metabolomic biomarkers as strong correlates of Parkinson disease progression
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DOI：
10.1212/wnl.0000000000003663
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发表时间：
2017-02-28
期刊：
影响因子：
9.9
通讯作者：
Auinger, Peggy
中科院分区：
文献类型：
--
作者：
LeWitt, Peter A.;Li, Jia;Auinger, Peggy
目的：确定帕金森病(PD)是否存在于全身代谢环境或脑脊液中，尤其是这种疾病的全身性表现超越了黑质纹状体多巴胺能神经元的进行性丧失。利用超高效液相色谱-气相色谱-串联质谱仪，我们测量了小分子(
Objective: To determine whether a Parkinson disease (PD)-specific biochemical signature might be found in the total body metabolic milieu or in the CSF compartment, especially since this disorder has systemic manifestations beyond the progressive loss of dopaminergic nigrostriatal neurons.Methods: Our goal was to discover biomarkers of PD progression. Using ultra-high-performance liquid chromatography linked to gas chromatography and tandem mass spectrometry, we measured concentrations of small-molecule (