Hydrogen bonds autonomously powered gelatin methacrylate hydrogels with super-elasticity, self-heal and underwater self-adhesion for sutureless skin and stomach surgery and E-skin
Hydrogen bonds autonomously powered gelatin methacrylate hydrogels with super-elasticity, self-heal and underwater self-adhesion for sutureless skin and stomach surgery and E-skin
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DOI：
10.1016/j.biomaterials.2018.04.023
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发表时间：
2018-07-01
期刊：
影响因子：
14
通讯作者：
Xing, Malcolm
中科院分区：
文献类型：
--
作者：
Liu, Bingcheng;Wang, Ying;Xing, Malcolm
界面交互诱导的自修复和自粘是一种宝石般的属性，灵感来自我们的大自然母亲。生物相容性甲基丙烯酸明胶（GeIMA）水凝胶具有可调的力学性能，有利于生物医学应用。然而，很难将高刚度、超弹性、大变形性和自愈性结合在一起。在这里，我们报道了一种基于geima的双网络（DN）水凝胶，利用单宁酸（TA）作为多功能氢键提供者，具有上述性能。我们首先研究了不同TA浓度和处理时间对GeIMA形貌和力学性能的影响。与原始GeIMA水凝胶（10% w/v）相比，GeIMA- ta水凝胶的极限应力（4.3倍），压缩模量（2.5倍），特别是伸长率（6倍）显著增加。GeIMA-TA的粘附性能可以通过TA调节，并已被证明是防水的。为了验证凝胶在体内的可行性，我们将GeIMA-TA凝胶应用于皮肤伤口和胃切口，无需缝合。结果表明，该凝胶具有促进伤口愈合的能力，具有良好的组织修复和最小的组织粘连。此外，与碳纳米管集成，geima - ta -碳纳米管凝胶是一种具有应变敏感导电性的自修复电皮肤。这项工作展示了一种生产创新生物医学应用的机械强水凝胶粘合剂的策略。(C) 2018 Elsevier Ltd.版权所有。
Interface-interaction induced self-healing and self-adhesive are a gem-like attribute inspired by our Mother Nature. Biocompatible gelatin methacrylate (GeIMA) hydrogels exhibit tunable mechanical properties which are favorable in biomedical applications. However, it is difficult to integrate high stiffness, super-elasticity, large deformability and self-healing property together. Here, we report a GeIMA-based double-network (DN) hydrogel with above properties by utilizing tannic acid (TA) as a multi-functional H-bond provider. We first investigated the morphological and mechanical properties' changes of GeIMA over different TA's concentrations and treating times. In comparison to pristine GeIMA hydrogel (10% w/v), the GeIMA-TA hydrogels presented significant increase in ultimate stress (4.3-fold), compressive modulus (2.5-fold), and especially in elongation (6-fold). Adhesion properties of GeIMA-TA can be tuned by TA and have been proven to be water-resistant. To test gels' feasibility in vivo, we applied GeIMA-TA gels to close skin wound and gastric incision without suture. The results indicated the gels had the capabilities of promoting wound healing with superior tissue restoration and minimal tissue adhesion. Furthermore, integrated with carbon nanotubes, the GeIMA-TA-carbon nanotube gel was an alternative self-healing electric skin with strain-sensitive conductivity. This work demonstrated a strategy to yield mechanically strong hydrogel adhesives for innovative biomedical applications. (C) 2018 Elsevier Ltd. All rights reserved.