Transcranial Alternating Current Stimulation Modulates Large-Scale Cortical Network Activity by Network Resonance
Transcranial Alternating Current Stimulation Modulates Large-Scale Cortical Network Activity by Network Resonance
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DOI：
10.1523/jneurosci.5867-12.2013
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发表时间：
2013-07-03
影响因子：
5.3
通讯作者：
Frohlich, Flavio
中科院分区：
文献类型：
--
作者：
Ali, Mohsin M.;Sellers, Kristin K.;Frohlich, Flavio
经颅直流电刺激（tDCS）已成为一种潜在的安全和有效的脑刺激方式，通过使小的恒定电流通过头皮来改变皮质兴奋性。tDCS产生电场，其微弱地调节大量皮质神经元的膜电压。最近的人体研究表明，正弦波刺激波形[经颅交流电刺激（tACS）]代表了一种更有针对性的刺激模式，用于增强皮层振荡。然而，周期性的，弱的全球扰动如何改变大规模皮层网络动力学的时空动力学的基本机制仍然是一个有争议的问题。在这里，我们模拟了大规模的尖峰神经元模型网络，以解决内源性节律网络中的这个问题。我们确定了不同的作用，tACS的去极化和超极化阶段的夹带，这需要移动网络活动朝向和远离一个强的非线性提供的局部兴奋性耦合的锥体细胞。这些机制共同产生了以网络共振频率为中心的Arnold舌的共振动力学。然后，我们进行了多通道细胞外记录的多单位放电活动在tACS在麻醉雪貂（Mustela pujetfuro），一个模型物种与脑回，以验证弱的全球扰动可以选择性地增强振荡在所施加的刺激频率。总之，这些结果提供了一个详细的机械理解tACS在大规模网络动态的水平，并支持未来的设计活动依赖性反馈tACS范例，动态定制刺激频率的频谱峰值正在进行的大脑活动。
Transcranial direct current stimulation (tDCS) has emerged as a potentially safe and effective brain stimulation modality that alters cortical excitability by passing a small, constant electric current through the scalp. tDCS creates an electric field that weakly modulates the membrane voltage of a large number of cortical neurons. Recent human studies have suggested that sine-wave stimulation waveforms [transcranial alternating current stimulation (tACS)] represent a more targeted stimulation paradigm for the enhancement of cortical oscillations. Yet, the underlying mechanisms of how periodic, weak global perturbations alter the spatiotemporal dynamics of large-scale cortical network dynamics remain a matter of debate. Here, we simulated large-scale networks of spiking neuron models to address this question in endogenously rhythmic networks. We identified distinct roles of the depolarizing and hyperpolarizing phases of tACS in entrainment, which entailed moving network activity toward and away from a strong nonlinearity provided by the local excitatory coupling of pyramidal cells. Together, these mechanisms gave rise to resonance dynamics characterized by an Arnold tongue centered on the resonance frequency of the network. We then performed multichannel extracellular recordings of multiunit firing activity during tACS in anesthetized ferrets (Mustela putoris furo), a model species with a gyrencephalic brain, to verify that weak global perturbations can selectively enhance oscillations at the applied stimulation frequency. Together, these results provide a detailed mechanistic understanding of tACS at the level of large-scale network dynamics and support the future design of activity-dependent feedback tACS paradigms that dynamically tailor stimulation frequency to the spectral peak of ongoing brain activity.