Inverse psoriasis involving genital skin folds: successful therapy with dapsone.
Inverse psoriasis involving genital skin folds: successful therapy with dapsone.
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DOI：
10.1007/s13555-012-0015-5
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发表时间：
2012-12
影响因子：
3.4
通讯作者：
Correa, Julio
中科院分区：
文献类型：
--
作者：
Guglielmetti, Antonio;Conlledo, Rodrigo;Bedoya, Juliana;Ianiszewski, Francisco;Correa, Julio
逆型牛皮癣是一种罕见的牛皮癣，影响3%至7%的牛皮癣患者。它可以包括生殖器皮肤褶皱作为生殖器牛皮癣的一部分，它是该地区最常见的皮肤病之一。很少有循证研究关于治疗三期牛皮癣涉及生殖器皮肤褶皱。作者报告一位42岁的女性患者，在外阴、腹股沟和肛周区域有红斑斑块。患者先前接受过广泛的局部和全身治疗，由于无效或副作用不得不停止。患者每日应用100毫克氨苯砜治疗10个月，皮肤和粘膜病变明显改善。治疗4周后观察到银屑病病灶完全清除。患者仅使用0.1%他克莫司和钙化三醇局部治疗，缓解期长达2年。生殖器牛皮癣是一种引起极大不适的皮肤病。重要的是要包括生殖器区域的检查，并在日常临床实践中采取这种行为。该领域的研究仍然很差，没有对弯曲型和生殖器型牛皮癣进行区分，并且基于病例系列和专家意见；因此，治疗生殖器牛皮癣的经验建议仍然存在。氨苯砜已被证明是一种有效和方便的替代治疗逆行银屑病在生殖器皮肤褶皱，它可以提供有效的控制疾病。需要进一步的研究来确定当前治疗方法的有效性和安全性，并决定当局部和其他全身药物无效时，是否应考虑使用氨苯砜治疗这种形式的牛皮癣。
Inverse psoriasis is a rare form of psoriasis that affects between 3% and 7% of the patients with psoriasis. It can comprise genital skin folds as part of genital psoriasis, and it is one of the most commonly seen dermatoses of this area. There are few evidence-based studies about the treatment of intertriginous psoriasis involving genital skin folds. The authors present a 42-year-old female patient with erythematous plaques in the vulva, groin, and perianal region. The patient had previously received a broad range of topical and systemic therapies that had to be discontinued due to ineffectiveness or side effects. She was treated with 100 mg dapsone daily for 10 months, showing a significant improvement of her cutaneous and mucous lesions. Complete clearance of psoriatic lesions was observed after 4 weeks of treatment. She has remained in remission for up to 2 years, using only topical therapy with tacrolimus 0.1% and calcipotriol. Genital psoriasis is a skin disease that causes great discomfort. It is important to include examination of the genital region and to adopt this conduct in daily clinical practice. Research in this field is still poor, making no discrimination between flexural and genital psoriasis, and is based on case series and expert opinion; therefore, empirical recommendations for the treatment of genital psoriasis remain. Dapsone has been shown to be an effective and convenient alternative for the treatment of inverse psoriasis in genital skin folds, which can provide effective control of the disease. Further studies are required to determine the efficacy and safety of current therapies, and to decide whether dapsone therapy should be considered in the management of this form of psoriasis when topical and other systemic agents are not effective.