Effects of increased systemic blood pressure on the tissue fluid pressure threshold of peripheral nerve.
Effects of increased systemic blood pressure on the tissue fluid pressure threshold of peripheral nerve.
复制标题
全身血压升高对周围神经组织液压力阈值的影响。
DOI：
10.1002/jor.1100010208
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Hargens,AR
中科院分区：
文献类型：
--
作者：
Szabo,RM;Gelberman,RH;Williamson,RV;Hargens,AR
本研究旨在评估高血压患者腕部正中神经对不同程度急性局部压迫的功能反应。在测量了9名受试者非优势手腕管中的静息组织液压力(舒张压大于或等于90 mm Hg)后，对手腕掌侧施加50、60或70 mm Hg的局部压力。在压迫前、压迫30-240分钟和压迫后恢复期评估正中神经的运动和感觉潜伏期和波幅。用灯芯导管技术测量，当阈值组织液压力为60-70 mm Hg时，感觉反应被完全阻断。这一压力阈值高于以前在正常血压受试者中发现的40-50毫米汞柱。正常血压和高血压受试者的组织压力阈值始终低于舒张压30毫米汞(比平均动脉压低约45毫米汞)。这些结果支持缺血是低压神经压迫综合征传导阻滞的主要机制的观点。
This study was designed to evaluate the functional response of the median nerve at the wrist to various degrees of acute, local compression in hypertensive patients. After measuring resting tissue fluid pressure in the carpal tunnel of the nondominant hand of nine subjects (diastolic pressures of 90 mm Hg or greater), localized pressures of 50, 60, or 70 mm Hg were applied to the palmar aspect of the wrist. Motor and sensory latencies and amplitudes of the median nerve were evaluated before compression, during 30–240 min of compression, and during the postcompression recovery phase. Sensory responses were completely blocked at a threshold tissue fluid pressure of 60–70 mm Hg, measured by the wick catheter technique. This pressure threshold was greater than the 40–50 mm Hg previously found in normotensive subjects. The tissue pressure threshold of normotensive and hypertensive subjects was consistently 30 mm Hg below diastolic blood pressure (approximately 45 mm Hg below mean arterial blood pressure). These results support the concept that ischemia is the prime mechanism of conduction block in low pressure, nerve‐compression syndromes.