Quantitative and Volumetric European Association for the Study of the Liver and Response Evaluation Criteria in Solid Tumors Measurements: Feasibility of a Semiautomated Software Method to Assess Tumor Response after Transcatheter Arterial Chemoembolization
Quantitative and Volumetric European Association for the Study of the Liver and Response Evaluation Criteria in Solid Tumors Measurements: Feasibility of a Semiautomated Software Method to Assess Tumor Response after Transcatheter Arterial Chemoembolization
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DOI：
10.1016/j.jvir.2012.08.028
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发表时间：
2012-12-01
影响因子：
2.9
通讯作者：
Geschwind, Jean-Francois
中科院分区：
文献类型：
--
作者：
Lin, MingDe;Pellerin, Olivier;Geschwind, Jean-Francois
目的：为了表明可以以时间高效且可重复的方式逐个体素获得肝脏肿瘤体积和增强模式测量结果，以提供真正的三维（3D）体积评估。材料和方法：回顾性评估了从20名招募用于单机构前瞻性研究的患者中获得的磁共振（MR）成像数据。所有患者均诊断为肝细胞癌（HCC），并首次接受药物洗脱珠（DEB）经导管动脉化疗栓塞。所有患者在DEB经导管动脉化疗栓塞前后均接受了对比增强MR成像; 3例患者因图像质量差而被排除，最终计数为17例患者。测量容积RECIST（vRECIST）和定量EASL（qEASL），并记录分割和处理时间。半自动分割的时间为65秒+/- 33（范围，40-200秒）。结论：半自动定量肿瘤增强（qEASL）和体积（vRECIST）评估在工作流程有效的时间范围内是可行的。临床相关性是必要的，但vRECIST和qEASL可以成为介入放射科医生评估动脉内治疗的一部分。
Purpose: To show that hepatic tumor volume and enhancement pattern measurements can be obtained in a time-efficient and reproducible manner on a voxel-by-voxel basis to provide a true three-dimensional (3D) volumetric assessment.Materials and Methods: Magnetic resonance (MR) imaging data obtained from 20 patients recruited for a single-institution prospective study were retrospectively evaluated. All patients had a diagnosis of hepatocellular carcinoma (HCC) and underwent drug-eluting beads (DEB) transcatheter arterial chemoembolization for the first time. All patients had undergone contrast-enhanced MR imaging before and after DEB transcatheter arterial chemoembolization; poor image quality excluded 3 patients, resulting in a final count of 17 patients. Volumetric RECIST (vRECIST) and quantitative EASL (qEASL) were measured, and segmentation and processing times were recorded.Results: There were 34 scans analyzed. The time for semiautomatic segmentation was 65 seconds +/- 33 (range, 40-200 seconds). vRECIST and qEASL of each tumor were computed < 1 minute for each.Conclusions: Semiautomatic quantitative tumor enhancement (qEASL) and volume (vRECIST) assessment is feasible in a workflow-efficient time frame. Clinical correlation is necessary, but vRECIST and qEASL could become part of the assessment of intraarterial therapy for interventional radiologists.