The role of activated macrophages in specific and nonspecific cytostasis of tumor cells.
The role of activated macrophages in specific and nonspecific cytostasis of tumor cells.
复制标题
活化的巨噬细胞在肿瘤细胞的特异性和非特异性细胞抑制中的作用。
DOI：
10.4049/jimmunol.113.2.507
复制
发表时间：
1974
影响因子：
4.4
通讯作者：
Jack S. Remington
中科院分区：
文献类型：
--
作者：
J. Krahenbuhl;Jack S. Remington
腹膜巨噬细胞对多种肿瘤靶细胞有明显的抑制作用，而细胞内原虫慢性感染小鼠的腹膜淋巴细胞对多种肿瘤靶细胞有明显的抑制作用。用原虫激活的巨噬细胞体外培养6小时内，定量检测L细胞、EMT-6腺肉瘤和同基因淋巴瘤对~3H-TdR摄取的抑制作用。未受刺激的小鼠或腹腔注射的小鼠的正常巨噬细胞对细胞有轻微的抑制作用或无抑制作用。用淀粉或硫代乙酸酯。原虫激活的巨噬细胞对几种肿瘤靶细胞的抑制能力是非特异性的，而与组织相容无关，而同种异体小鼠淋巴瘤细胞免疫的近交系小鼠的巨噬细胞表现出特异性的细胞抑制。
Peritoneal macrophages but not peritoneal lymphocytes from mice chronically infected with the intracellular protozoan parasites Toxoplasma gondii and Besnoitia jellisoni had a marked cytostatic effect on a variety of tumor target cells. Cytostasis was quantitatively measured as an inhibition in uptake of tritium labeled thymidine (3H-TdR) by L cells, EMT-6 adenosarcoma, and lymphomas syngeneic for DBA/2 and C57BL mice within 6 hr after culture in vitro with protozoal-activated macrophages. Slight or no cytostasis was effected by normal macrophages from unstimulated mice or mice injected i.p. with starch or thioglycollate. Whereas the cytostatic capabilities of protozoal activated macrophages were directed nonspecifically against several types of tumor target cells regardless of histocompatability, specific cytostasis was demonstrated by macrophages from inbred mice immunized with allogeneic mouse lymphoma cells.