Optical dispersions through intracellular inhomogeneities
Optical dispersions through intracellular inhomogeneities
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DOI：
10.1103/physrevresearch.5.l022043
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发表时间：
2022-07
期刊：
影响因子：
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通讯作者：
M. Watabe;Yasuhiro Hirano;A. Iwane;O. Matoba;Koichi Takahashi
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文献类型：
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作者：
M. Watabe;Yasuhiro Hirano;A. Iwane;O. Matoba;Koichi Takahashi
强度方程（TIE）的传输表现出中间场（例如，光和电子）在生物成像中。先前的TIE公式通常假设单色相干场函数的自由空间传播沿着纵向方向沿着穿过相位分布。在这里，我们修改TIE分形（或自相似）组织模型的基础上细胞内折射率湍流。然后，我们实现了广泛的分形维数和波长的TIE模拟。模拟结果表明，如何通过细胞内折射率的空间波动的强度传播互连分形维数与强度色散（或transmittance）在皮米到微米波长范围内。此外，我们提供了一个空间自相关的相位导数，允许直接测量和重建细胞内的分形分布从光学和电子显微镜成像。
Transport of intensity equation (TIE) exhibits a non-interferometric correlation between intensity and phase variations of intermediate fields (e.g., light and electron) in biological imaging. Previous TIE formulations have generally assumed a free space propagation of monochromatic coherent field functions crossing phase distributions along a longitudinal direction. Here, we modify the TIE with fractal (or self-similar) organization models based on intracellular refractive index turbulence. We then implement the TIE simulation over a broad range of fractal dimensions and wavelengths. Simulation results show how the intensity propagation through the spatial fluctuation of intracellular refractive index interconnects fractal-dimensionality with intensity dispersion (or transmissivity) within the picometer to micrometer wavelength range. In addition, we provide a spatial-autocorrelation of phase derivatives which allows the direct measurement and reconstruction of intracellular fractal profiles from optical and electron microscopy imaging.