Using drug-discrimination techniques to study the abuse-related effects of psychoactive drugs in rats
Using drug-discrimination techniques to study the abuse-related effects of psychoactive drugs in rats
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DOI：
10.1038/nprot.2006.167
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发表时间：
2006-01-01
期刊：
影响因子：
14.8
通讯作者：
Goldberg, Steven R.
中科院分区：
文献类型：
--
作者：
Solinas, Marcello;Panlilio, Leigh V.;Goldberg, Steven R.
药物歧视（DD）技术可用于通过建立训练药物（例如可卡因）的内感受效应作为执行特定操作反应（例如通过食物强化杠杆按压）的提示来研究滥用相关效应。在使用该方案进行训练期间，当在训练开始前注射训练药物时，按下一个控制杆会得到加强，而当在训练前注射媒介物时，会加强对第二个控制杆的响应。测试过程中的杠杆选择可以用来指示新药是否具有与训练药物相似的效果，或者潜在的治疗方法是否会改变训练药物的效果。尽管培训可能很长（长达几个月），但 DD 程序的药理学特异性使其成为用于研究药物滥用现象的其他技术的完美补充，例如静脉自我给药和条件性位置偏好程序。
Drug-discrimination (DD) techniques can be used to study abuse-related effects by establishing the interoceptive effects of a training drug (e.g., cocaine) as a cue for performing a specific operant response (e.g., lever pressing reinforced by food). During training with this protocol, pressing one lever is reinforced when the training drug is injected before the start of the session, and responding on a second lever is reinforced when vehicle is injected before the session. Lever choice during test sessions can then be used as an indication of whether a novel drug has effects similar to the training drug, or whether a potential therapeutic alters the effects of the training drug. Although training can be lengthy (up to several months), the pharmacological specificity of DD procedures make them a perfect complement to other techniques used to study drug-abuse phenomena, such as intravenous self-administration and conditioned place-preference procedures.