No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population
No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population
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DOI：
10.1016/j.schres.2006.12.020
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发表时间：
2007-03-01
影响因子：
4.5
通讯作者：
Iwata, Nakao
中科院分区：
文献类型：
--
作者：
Ikeda, Masashi;Ozaki, Norio;Iwata, Nakao
关于精神分裂症的尸检研究显示，与伽马-氨基丁酸神经传递系统相关的基因表达发生了变化。最一致的发现之一是67 kDa谷氨酸脱羧酶亚型(GAD(67))水平降低。此外，几项研究报告了GAD(67)基因(GAD1)与精神分裂症的正相关。这些原因促使我们在日本人群(562名精神分裂症患者和470名对照)中开展了关于GAD1(14个标记SNPs)与精神分裂症相关性的重复研究。然而，我们无法证实之前报道的重大关联。考虑到我们的样本大小和策略与基于基因的关联分析中使用的方法很好地一致，我们的结论是GAD1在日本人群中不是精神分裂症的主要角色。(C)2007 Elsevier B.V.保留所有权利。
Postmortem studies regarding schizophrenia revealed altered expression of genes related to gamma-amino butyric acid neurotransmission system. One of the most consistent findings is the reduced level of 67 kDa glutamic acid decarboxylase isoform (GAD(67)). Moreover, several studies reported positive associations between the GAD(67) gene (GAD1) and schizophrenia. These reasons, motivated us to carry out replication study regarding association between GAD1 (fourteen tagging SNPs) and schizophrenia in Japanese population (562 schizophrenic patients and 470 controls). However we couldn't confirm significant association that had been previously reported. Considering size of our sample and strategy that corresponds well with the approaches used in gene-based association analysis, our conclusion is that GAD1 does not play a major role in schizophrenia in Japanese population. (c) 2007 Elsevier B.V. All rights reserved.