LACUNES - SMALL DEEP CEREBRAL INFARCTS
LACUNES - SMALL DEEP CEREBRAL INFARCTS
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DOI：
10.1212/wnl.15.8.774
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发表时间：
1965-01-01
期刊：
影响因子：
9.9
通讯作者：
FISHER, CM
中科院分区：
文献类型：
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作者：
FISHER, CM
在尸检的1，042人中，114人发现了376个脑陷窝。研究了骨陷窝的发生率、数量、位置和大小。最常见的降序参与豆状核，脑桥，丘脑，尾状核，和内囊放射冠区。腔隙与高血压和脑动脉粥样硬化的关系现已得到充分证实。腔隙与颈内动脉疾病、脑栓塞或糖尿病无关。在这些患者入住普通内科病房的病例中，通常没有卒中史，即使有，由于细节不完整以及尸检发现的病变（梗死和出血）的多样性和复杂性，也不可能有良好的临床病理学相关性。在这个系列中，晚期假性延髓麻痹和痴呆显然是文献中的这些体征，可能是研究特别选择的病例的结果。目前只能推测引起动脉损伤的原因，需要进一步研究血管过程。
Of 1,042 persons examined at autopsy, 376 cerebral lacunes were found in 114. The lacunes were studied in regard to incidence, number, location, and size. Most frequently involved in descending order were the lenticular nucleus, pons, thalamus, caudate, and internal capsule-corona radiata region. A relationship of lacunes to hypertension and cerebral atherosclerosis has now been amply confirmed. Lacunes were not related to internal carotid artery disease, cerebral embolism, or diabetes. In these cases in which the patient was admitted to the general medical wards there was usually no history of a stroke and, if there was, a good clinicopathologic correlation was impossible becuase of incomplete details, as well as the multiplicity and complexity of the lesions found at autospy (infarction and hemorrhage). In this series, advanced pseudobulbar palsy and dementia were apparently these signs in the literature has probably been the result of studying specially selected cases. The responsible arterial lesion can at present only be surmised, and there is a need for further studies of the vascular process.