Connective Tissue Disease-Associated Interstitial Lung Disease A Call for Clarification
Connective Tissue Disease-Associated Interstitial Lung Disease A Call for Clarification
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DOI：
10.1378/chest.10-0194
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发表时间：
2010-08-01
期刊：
影响因子：
9.6
通讯作者：
du Bois, Roland M.
中科院分区：
文献类型：
--
作者：
Fischer, Aryeh;West, Sterling G.;du Bois, Roland M.
这篇评论强调了目前围绕着一个有相关结缔组织疾病的临床特征，但在目前的风湿病分类系统下，这些特征不足以明确诊断结缔组织疾病相关的间质性肺疾病的间质性肺炎患者的分类问题。这篇评论说明了我们认为目前对这组患者进行分类的方法的局限性，并讨论了重新定义未分化结缔组织疾病的诊断以包括间质性肺炎患者的问题。最后，我们主张不仅采用多学科方法进行评估，而且还进行疾病分类，并建议将其定义为一种独特的表型肺显性ctd，以便在未来的多机构研究中测试预后，治疗和病理意义。胸部2010;138 (2): 251 - 256
This commentary highlights the present dilemmas surrounding the classification of a patient with interstitial pneumonia who has clinical features suggesting an associated connective tissue disease but the features fall short of a clear diagnosis of connective tissue disease-associated interstitial lung disease under the current rheumatologic classification systems. This commentary illustrates what we perceive to be the limitations in the present approach to the classification of this group of patients and discusses problems with redefining the diagnosis of undifferentiated connective tissue disease to encompass patients with interstitial pneumonia. Finally, we advocate not only for a multidisciplinary approach to evaluation, but also disease classification and offer a proposal to define them as a distinct phenotype lung-dominant CTD-for which prognostic, therapeutic, and pathobiologic implications can be tested in future, hopefully multiinstitutional, studies. CHEST 2010; 138(2):251-256