Zinc finger proteins: new insights into structural and functional diversity
Zinc finger proteins: new insights into structural and functional diversity
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DOI：
10.1016/s0959-440x(00)00167-6
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发表时间：
2001-02-01
影响因子：
6.8
通讯作者：
Wright, PE
中科院分区：
文献类型：
--
作者：
Laity, JH;Lee, BM;Wright, PE
锌指蛋白是真核基因组中最丰富的蛋白质之一。它们的功能极其多样，包括 DNA 识别、RNA 包装、转录激活、细胞凋亡调节、蛋白质折叠和组装以及脂质结合。锌指结构与其功能一样多种多样。最近报道了许多具有新颖拓扑的新锌指结构域的结构，为结构/功能关系提供了重要的见解。此外，对含有经典 CYs(2)His(2) 锌指基序的蛋白质的新结构研究带来了对 DNA 结合机制的新见解，并更好地了解了它们在转录调控中的更广泛功能。
Zinc finger proteins are among the most abundant proteins in eukaryotic genomes. Their functions are extraordinarily diverse and include DNA recognition, RNA packaging, transcriptional activation, regulation of apoptosis, protein folding and assembly, and lipid binding. Zinc finger structures are as diverse as their functions. Structures have recently been reported for many new zinc finger domains with novel topologies, providing important insights into structure/function relationships. In addition, new structural studies of proteins containing the classical CYs(2)His(2) zinc finger motif have led to novel insights into mechanisms of DNA binding and to a better understanding of their broader functions in transcriptional regulation.