Stability of Weakly Acidic Hypochlorous Acid Solution with Microbicidal Activity
Stability of Weakly Acidic Hypochlorous Acid Solution with Microbicidal Activity
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DOI：
10.4265/bio.22.223
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发表时间：
2017-12-01
影响因子：
1.2
通讯作者：
Yokoe, Hidetaka
中科院分区：
文献类型：
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作者：
Ishihara, Masayuki;Murakami, Kaoru;Yokoe, Hidetaka
制备次氯酸 (HOCI) 溶液（200 ppm，pH 6）并评估其稳定性和杀菌活性。我们证明 HOCI 对紫外线 (UV)、阳光、与空气接触和高温 (>= 25 摄氏度) 不稳定。此外，HOCI溶液中过量存在的含NH2-或CHO的有机化合物如蛋白质、碳水化合物，或无机离子如NO2-、SO3-、PO3-、Fe2+、Cu2+、CuS等的存在，导致HOCI通过氧化反应快速消耗，显着降低HOCI溶液对大肠菌群的杀菌活性。 细菌和活细胞总数。因此，生产稳定的 HOCI 溶液需要在各种化合物和离子浓度尽可能低的纯水中配制，并在黑暗和凉爽的条件下储存（
Hypochlorous acid (HOCI) solution (200 ppm, pH 6) was prepared and evaluated for their stabilities and microbicidal activities. We demonstrated that HOCI is unstable against ultraviolet (UV) light, sunshine, contact with air, and elevated temperature (>= 25 degrees C). Furthermore, in the HOCI solution, the presence of excess NH2- or CHO-containing organic compounds such as proteins and carbohydrates, or of inorganic ions such as NO2-, SO3-, PO3-, Fe2+, Cu2+, and CuS, resulted in the rapid consumption of HOCI by oxidation reactions, and significantly decreased the microbicidal activity of the HOCI solution against coliform bacteria and total viable cell count. Thus, production of stable HOCI solution requires formulation in pure water harboring concentrations as low as possible of various compounds and ions, as well as storage in dark and cool conditions (