Feasibility of 18F-FDG Dose Reductions in Breast Cancer PET/MRI
Feasibility of 18F-FDG Dose Reductions in Breast Cancer PET/MRI
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DOI：
10.2967/jnumed.118.209007
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发表时间：
2018-12-01
影响因子：
9.3
通讯作者：
Veit-Haibach, Patrick
中科院分区：
文献类型：
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作者：
Sah, Bert-Ram;Ghafoor, Soleen;Veit-Haibach, Patrick
本研究的目的是确定乳腺癌患者在飞行时间PET/MRI中临床可接受的F-18-FDG剂量降低水平。方法：连续26例经组织学证实的乳腺癌患者（中位年龄51岁，范围34-83岁）进行了分析。通过取消列出PET/MRI上的列表模式数据生成模拟剂量降低PET图像。采集的20分钟PET帧以5种方式重建：前2分钟的重建，3次迭代和28个参考子集，以及模拟原始剂量的100%、20%、10%和5%的重建。使用4分量表分析一般图像质量和伪影、图像清晰度、图像噪声和病变可检测性。使用非参数Friedman检验对多个样本进行定性参数比较，使用Wilcoxon符号秩检验对配对样本进行定性参数比较。使用Mann-Whitney U检验比较不同组的独立样本。结果：总共评价了355个病变（71个病变，每个病变有5种不同的重建）。100%注射剂量的20分钟重建在所有类别中显示出最好的结果。对于一般图像质量和伪影、图像清晰度和噪声，模拟剂量为20%和10%的重建明显优于2分钟重建（P
The goal of this study was to determine the level of clinically acceptable F-18-FDG dose reduction in time-of-flight PET/MRI in patients with breast cancer. Methods: Twenty-six consecutive women with histologically proven breast cancer were analyzed (median age, 51 y; range, 34-83 y). Simulated dose-reduced PET images were generated by unlisting the list-mode data on PET/MRI. The acquired 20-min PET frame was reconstructed in 5 ways: a reconstruction of the first 2 min with 3 iterations and 28 subsets for reference, and reconstructions simulating 100%, 20%, 10%, and 5% of the original dose. General image quality and artifacts, image sharpness, image noise, and lesion detectability were analyzed using a 4-point scale. Qualitative parameters were compared using the nonparametric Friedman test for multiple samples and the Wilcoxon signed-rank test for paired samples. Different groups of independent samples were compared using the Mann-Whitney U test. Results: Overall, 355 lesions (71 lesions with 5 different reconstructions each) were evaluated. The 20-min reconstruction with 100% injected dose showed the best results in all categories. For general image quality and artifacts, image sharpness, and noise, the reconstructions with a simulated dose of 20% and 10% were significantly better than the 2-min reconstructions (P