A careful disorderliness in the proteome: Sites for interaction and targets for future therapies
A careful disorderliness in the proteome: Sites for interaction and targets for future therapies
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DOI：
10.1016/j.febslet.2008.02.027
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发表时间：
2008-04-09
期刊：
影响因子：
3.5
通讯作者：
Gibson, Toby J.
中科院分区：
文献类型：
--
作者：
Russell, Robert B.;Gibson, Toby J.
近年来，出现了对研究本质上非结构化（或无序）蛋白质感兴趣的科学家群体。一开始作为一个有争议的想法已经成为一个既定的现象。新的，更大的关注蛋白质，在某种程度上通常是非结构化的承诺，提供了一个更好的了解蛋白质的功能，特别是在蛋白质-蛋白质相互作用。这些区域也为小分子如何靶向相互作用提供了新的可能性。(C)2008年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
The community of scientists interested in studying intrinsically unstructured (or disordered) proteins has emerged in recent years. What began as a controversial idea has become an established phenomenon. The new, greater focus on proteins that are in some way normally unstructured promises to provide a greater understanding of protein function, particularly with respect to protein-protein interactions. These regions also offer new possibilities into how interactions can be targeted by small molecules. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.