Premature menopause is associated with increased risk of cerebral infarction in Japanese women
Premature menopause is associated with increased risk of cerebral infarction in Japanese women
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DOI：
10.1097/gme.0b013e3181c7dd41
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发表时间：
2010-05-01
影响因子：
2.7
通讯作者：
Kajii, Eiji
中科院分区：
文献类型：
--
作者：
Baba, Yosuke;Ishikawa, Shizukiyo;Kajii, Eiji
目的：很少有流行病学研究探讨绝经年龄和中风发病率之间的关系，也没有一项研究在日本妇女中进行过。在这里，我们在一大群日本妇女中调查了绝经年龄和中风发病率的关系。方法：研究参与者是4790名年龄在36岁到89岁之间的绝经后妇女，参加了济济医学院队列研究，这是一项基于人群的前瞻性研究。基线数据是从1992年4月至1995年7月在日本12个农村地区通过问卷调查和健康检查获得的。结果：受试者平均年龄为61.0岁(6.7岁)，绝经时平均年龄为48.3岁(4.8岁)。在平均10.8年的随访期内，共观察到185次中风。在对年龄、收缩压、总胆固醇、体重指数、吸烟习惯和饮酒习惯进行调整后，40岁以前、40~44岁、45~49岁、55岁或以后绝经女性与50~54岁绝经女性相比，中风的危险比(95%CI)分别为1.56(0.78-3.12)、1.59(1.00-2.51)、1.28(0.92-1.78)和0.83(0.38-1.81)。而绝经年龄在40岁以前、40~44岁、45~49岁、55岁或以后的绝经妇女与50~54岁绝经妇女相比，脑梗塞的危险比(95%CI)分别为2.57(1.20~5.49)、1.49(0.80~2.78)、1.06(0.67~1.68)和1.08(0.43~2.74)。提前绝经应该被认为是需要更积极的医学干预以预防脑梗塞的一个指标。
Objective: Few epidemiological studies have examined the relationship between age at menopause and stroke incidence, and none have done so in Japanese women. Here, we investigated the relationship between age at menopause and stroke incidence in a large group of Japanese women.Methods: The study participants were 4,790 postmenopausal women aged 36 to 89 years enrolled in the Jichi Medical School Cohort Study, a population-based prospective study. Baseline data were obtained by questionnaire and health checkups between April 1992 and July 1995 in 12 rural areas in Japan. The incidence of all strokes and stroke subtypes was monitored.Results: Mean (SD) participant age was 61.0 (6.7) years, and mean (SD) age at menopause was 48.3 (4.8) years. A total of 185 strokes were observed during a mean follow-up of 10.8 years. On adjustment for age, systolic blood pressure, total cholesterol, body mass index, smoking habits, and alcohol drinking habits, hazard ratios (95% CIs) of stroke for women who underwent menopause before age 40 years, at 40 to 44 years, at 45 to 49 years, and at 55 years or after relative to those who underwent menopause at age 50 to 54 years were 1.56 (0.78-3.12), 1.59 (1.00-2.51), 1.28 (0.92-1.78), and 0.83 (0.38-1.81), respectively. However, hazard ratios (95% CI) of cerebral infarction for women who underwent menopause before age 40 years, at 40 to 44 years, at 45 to 49 years, and at 55 years or after relative to those who underwent menopause at age 50 to 54 years were 2.57 (1.20-5.49), 1.49 (0.80-2.78), 1.06 (0.67-1.68), and 1.08 (0.43-2.74), respectively.Conclusions: Our data suggest that Japanese women who undergo menopause before age 40 years are at an increased risk of cerebral infarction. Premature menopause should be considered an indicator of the need for more aggressive medical intervention aimed at the prevention of cerebral infarction.