Personality and major depression - A Swedish longitudinal, population-based twin study
Personality and major depression - A Swedish longitudinal, population-based twin study
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DOI：
10.1001/archpsyc.63.10.1113
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发表时间：
2006-10-01
影响因子：
--
通讯作者：
Pedersen, Nancy L.
中科院分区：
文献类型：
--
作者：
Kendler, Kenneth S.;Gatz, Margaret;Pedersen, Nancy L.
内容：先前的研究表明，人格特质的神经质和外向性可能与重性抑郁症（MD）的易感性有关。目的：阐明神经质和外向性与MD风险之间的关联的大小和性质。设计：纵向人口为基础的双胞胎队列。设置：一般社区。参与者：共有20692名来自瑞典人口双胞胎登记处的同性双胞胎成员完成了自我检查，1972年和1973年报告问卷评估神经质和外向性，并亲自访问了超过25年的MD终身史主要结果指标：修订版DSM-IV MD的终生病史。结果：神经质水平强烈预测终生和新发MD的风险。双胞胎模型表明，神经质和MD之间的关联主要来自共同的遗传风险因素，遗传相关性为+0.46至+0.47。外向水平与终生和新发MD的风险呈弱负相关。当我们控制了神经质的水平时，这种效应就消失了。双胞胎模型产生了类似的结果。结论：从纵向和遗传分析的结果支持的假设，神经质强烈反映了MD的责任。这种关联的出现主要是因为神经质指数抑郁症的遗传风险。然而，相当大比例的遗传易感性，以MD并没有反映在神经质。相比之下，外向性与MD的风险只有微弱的相关性。
Context: Prior studies suggest that the personality traits of neuroticism and extroversion may be related to the liability to major depression ( MD).Objective: To clarify the magnitude and nature of the association between neuroticism and extroversion and the risk for MD.Design: Longitudinal population-based twin cohort.Setting: General community.Participants: A total of 20 692 members of same-sex twin pairs from the population-based Swedish Twin Registry who completed a self-report questionnaire assessing neuroticism and extroversion in 1972 and 1973 and were personally interviewed for lifetime history of MD more than 25 years later.Main Outcome Measure: Lifetime history of modified DSM-IV MD.Results: Levels of neuroticism strongly predicted the risks for both lifetime and new-onset MD. Twin modeling indicated that the association between neuroticism and MD resulted largely from shared genetic risk factors, with a genetic correlation of +0.46 to +0.47. Levels of extroversion were weakly and inversely related to the risks for lifetime and new-onset MD. This effect disappeared when we controlled for the level of neuroticism. Twin modeling produced similar results.Conclusions: Results from both longitudinal and genetic analyses support the hypothesis that neuroticism strongly reflects the liability to MD. This association arises largely because neuroticism indexes the genetic risk for depressive illness. However, substantial proportions of the genetic vulnerability to MD are not reflected in neuroticism. By contrast, extroversion is only weakly related to risk for MD.