A theory of cognitive control, aging cognition, and neuromodulation
A theory of cognitive control, aging cognition, and neuromodulation
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DOI：
10.1016/s0149-7634(02)00067-2
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发表时间：
2002-11-01
影响因子：
8.2
通讯作者：
Barch, DA
中科院分区：
文献类型：
--
作者：
Braver, TS;Barch, DA
一个理论，它的链接在正常老化的多巴胺（DA）系统投射到前额叶的功能下降的基础上观察到的认知变化。皮质（PFC）。该理论假设，这种神经机制是不可或缺的表征，维护和更新的背景信息，并因此影响认知控制在广泛的认知领域，包括工作记忆，注意力和抑制。行为和脑成像数据支持的理论进行了讨论，这表明选择性障碍的背景下处理与异常PFC激活的健康老年人。这些发现突出了认知老化的计算方法的实用性。目前的进一步完善和验证的模型的方向进行了概述。(C)2002爱思唯尔科技有限公司版权所有。
A theory is described which links cognitive changes observed in normal aging to an underlying decline in the function of the dopamine (DA) system projection to prefrontal. cortex (PFC). The theory postulates that this neural mechanism is integral to the representation, maintenance and updating of context information, and as such impacts cognitive control across a wide range of cognitive domains, including working memory, attention, and inhibition. Behavioral and brain imaging data in support of the theory are discussed, which demonstrate selective impairments in context processing among healthy older adults associated with abnormal PFC activation. These findings highlight the utility of a computational approach to cognitive aging. Current directions for further refinement and validation of the model are outlined. (C) 2002 Elsevier Science Ltd. All rights reserved.