Swimming exercise ameliorates depression-like behavior in chronically stressed rats: Relevant to proinflammatory cytokines and IDO activation
Swimming exercise ameliorates depression-like behavior in chronically stressed rats: Relevant to proinflammatory cytokines and IDO activation
复制标题
游泳运动可改善慢性应激大鼠的抑郁样行为：与促炎细胞因子和 IDO 激活相关
DOI：
10.1016/j.bbr.2012.12.041
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发表时间：
2013-04-01
影响因子：
2.7
通讯作者：
Ni, Xin
中科院分区：
文献类型：
--
作者：
Liu, Weina;Sheng, Hui;Ni, Xin
慢性压力与抑郁症的发展有关，并导致免疫系统的改变。吲哚胺-2,3-双加氧酶（IDO）在免疫激活反应中介导抑郁样行为中起关键作用。体育锻炼已被证明可以减少压力损害和改善抑郁症状。本研究旨在证实慢性不可预测轻度应激（chronic unpredictable mild stress， CUMS）在脑内诱导抑郁样行为和炎症反应，并探讨游泳运动是否通过促炎细胞因子诱导的脑IDO改变来缓解CUMS诱导的抑郁样行为。研究发现，CUMS暴露诱导抑郁样行为，血清皮质酮（CORT）水平升高，5-羟色胺水平降低，ifn - γ和tnf - α水平升高，前额皮质IDO活性升高。5-HT水平与IDO水平呈负相关。有规律的游泳运动可改善CUMS引起的抑郁症状。运动降低了CUMS大鼠血清CORT水平，增加了5-HT水平，降低了前额皮质ifn - γ、tnf - α和IDO水平。这些发现提示，CUMS激活HPA轴，诱导免疫激活，从而刺激IDO活性，导致脑内5-HT水平降低，从而导致抑郁。游泳运动可能抑制由CUMS引起的炎症/IDO通路的激活，从而改善抑郁症。(C) 2013 Elsevier B.V.版权所有
Chronic stress is involved in development of depression and causes immune alterations. Indoleamine-2,3-dioxygenase (IDO) plays a pivotal role in mediating the depression-like behaviors in response to immune activation. Physical exercise has been shown to reduce the stress impairment and ameliorate depressive symptoms. The objectives of present study were to confirm that chronic unpredictable mild stress (CUMS) induces depression-like behavior and inflammatory responses within the brain, and then investigate whether swimming exercise alleviates the depression-like behaviors induced by CUMS through proinflammatory cytokine-induced alteration of IDO in brain. It has been found that CUMS exposure induced depression-like behavior, increased serum corticosterone (CORT) level, decreased 5-HT level, increased IFN-gamma and TNF-alpha levels and elevated IDO activity in prefrontal cortex. Moreover, the level of 5-HT was inversely correlated with IDO level. Regular swimming exercise ameliorated depressive symptoms induced by CUMS. The exercise reduced serum CORT level, increased 5-HT level as well as decreased levels of IFN-gamma, TNF-alpha and IDO in prefrontal cortex in CUMS rats. These findings suggested that CUMS activate HPA axis and induce immune activation, which may stimulate IDO activity, leading to the reduction of 5-HT level in brain, thereby resulting in depression. Swimming exercise may inhibit activation of inflammation/IDO pathways induced by CUMS, thereby ameliorating depression. (C) 2013 Elsevier B.V. All rights reserved.