Vagotomy produces learned food aversions in the rat.
Vagotomy produces learned food aversions in the rat.
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迷走神经切断术使老鼠产生了习得的食物厌恶。
DOI：
10.1037//0735-7044.97.4.585
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发表时间：
1983
影响因子：
1.9
通讯作者：
Goehler,LE
中科院分区：
文献类型：
--
作者：
Bernstein,IL;Goehler,LE
两项实验，每一项都有28只雌性龙-埃文斯大鼠，研究了迷走神经切开术大鼠在食物摄入方面的一些抑郁是否可能是由于手术后对所吃食物产生厌恶。在实验1中，迷走神经切断术后对特定的新饮食产生了显著的厌恶，结果表明与迷走神经切断术相关的症状（吞咽不足、体重减轻、不适）可以作为习得性食物厌恶的有效ucs。实验II比较了迷走神经切除的小鼠食用熟悉的实验室食物与食用新食物的小鼠。与新饮食相比，对熟悉食物的习得性厌恶没有发展，吞咽不足也不那么持续和严重。由此可见，习得性食物厌恶有助于迷走神经动物的食欲和体重下降。考虑到在迷走神经切开术后出现这些厌恶的条件，可以允许设计研究，以尽量减少厌恶，从而将这些非特异性影响与迷走神经切开术产生的直接调节缺陷分开。（22 ref）（PsycINFO Database Record (c) 2016 APA，版权所有）
Two experiments, each with 28 female Long-Evans rats, examined whether some of the depression in food intake observed in rats with vagotomy could be due to the development of aversions to the foods eaten after surgery. In Exp I, significant aversions developed to the specific novel diet consumed after vagotomy, results indicating that the symptoms associated with vagotomy (hypophagia, weight loss, discomfort) can serve as effective UCSs in the acquisition of learned food aversions. Exp II compared vagotomized Ss consuming familiar laboratory chow with those consuming a novel diet. In contrast to the novel diets, learned aversions to the familiar chow did not develop and hypophagia was less persistent and severe. It is concluded that learned food aversions can contribute to the appetite and weight loss exhibited by vagotomized animals. Consideration of the conditions under which these aversions arise after vagotomy surgery may allow for the design of studies so as to minimize the aversions and thereby separate these nonspecific effects from direct regulatory deficits produced by vagotomy.(22 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)