Epidemiological and Clinical Findings of Short-Term Recurrence of Severe Acute Respiratory Syndrome Coronavirus 2 Ribonucleic Acid Polymerase Chain Reaction Positivity in 1282 Discharged Coronavirus Disease 2019 Cases: A Multicenter, Retrospective, Observational Study.
Epidemiological and Clinical Findings of Short-Term Recurrence of Severe Acute Respiratory Syndrome Coronavirus 2 Ribonucleic Acid Polymerase Chain Reaction Positivity in 1282 Discharged Coronavirus Disease 2019 Cases: A Multicenter, Retrospective, Observational Study.
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DOI：
10.1093/ofid/ofaa432
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发表时间：
2020-10
影响因子：
4.2
通讯作者：
Fang M
中科院分区：
文献类型：
--
作者：
Chen SL;Xu H;Feng HY;Sun JF;Li X;Zhou L;Song WL;Huang SS;He JL;Deng YY;Wang RJ;Fang M
2019冠状病毒病（COVID-19）出院患者中SARS-CoV-2核糖核酸（RNA）聚合酶链反应（PCR）阳性短期复发引起公众关注。本研究旨在确定此类患者的临床和流行病学结果。本研究对2020年1月14日至3月10日收治新冠肺炎出院患者的32家定点医院进行回顾性研究。随访28天后，再次检测出SARS-CoV-2 RNA阳性并经逆转录酶聚合酶链反应确诊的患者再次入院接受进一步治疗。再次检测阳性患者的密切接触者均被要求自我隔离14天。对这些患者的流行病学、症状、实验室检测和治疗数据进行分析，并对其密切接触者进行调查。在1282例出院患者中，189例（14.74%）在28天的随访中再次检测出SARS-CoV-2 RNA阳性。从出院到下一次阳性检测的中位时间为8天（四分位数间距[IQR]， 5-13）。再次检测阳性组患者更年轻（34岁vs 45岁，P < 0.001），首次住院时出现中度症状的比例（95.77% vs 84.35%, P < 0.001）高于阴性组。第二次住院时，再次检测阳性的患者外周血和淋巴细胞正常，无新发症状；78.31%的患者胸部ct扫描较首次出院改善，25.93%的患者接受了抗病毒治疗。从再阳性到阴性的中位时间为8 d （IQR, 4-15）。密切接触者均未出现新冠肺炎。我们的数据表明，出院患者SARS-CoV-2 RNA阳性短期复发不是COVID-19复发，继续传播的风险很低。这为管理COVID-19患者提供了重要信息。在这项涉及1282名出院的COVID-19患者的多中心研究中，随访28天，14.74%的患者再次检测出SARS-CoV-2 RNA阳性。然而，我们的数据表明，再阳性并不代表COVID-19复发，进一步传播的风险非常低。
Short-term recurrence of positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ribonucleic acid (RNA) polymerase chain reaction (PCR) in discharged coronavirus disease 2019 (COVID-19) patients attracts the public’s concern. This study aimed to determine the clinical and epidemiological results of such patients. This retrospective study was conducted on 32 designated hospitals for COVID-19 patients discharged from January 14 to March 10, 2020. After 28-day followed-up, patients who tested positive again for SARS-CoV-2 RNA and confirmed by reverse-transcriptase polymerase chain reaction were re-admitted to hospital for further treatments. All of the close contacts of patients who tested positive again were asked to self-segregate for 14 days. Data of epidemiology, symptoms, laboratory tests, and treatments were analyzed in those patients, and their close contacts were investigated. Of 1282 discharged patients, 189 (14.74%) tested positive again for SARS-CoV-2 RNA during 28-day follow-up. The median time from discharge to the next positive test was 8 days (interquartile range [IQR], 5–13). Patients in the group that tested positive again were younger (34 vs 45 years, P < .001) with a higher proportion of moderate symptoms (95.77% vs 84.35%, P < .001) in the first hospitalization than in the negative group. During the second hospitalization, all patients who tested positive again showed normal peripheral white blood cells and lymphocytes and no new symptoms of COVID-19; 78.31% further improved on chest computed tomography scan compared with the first discharge, yet 25.93% accepted antiviral therapy. The median time of re-positive to negative test was 8 days (IQR, 4–15). None of the close contacts developed COVID-19. Our data suggest that the short-term recurrence of positive SARS-CoV-2 RNA in discharged patients is not a relapse of COVID-19, and the risk of onward transmission is very low. This provides important information for managing COVID-19 patients. In this multicenter study involving 1282 discharged COVID-19 patients with 28-day follow-up, 14.74% tested positive again for SARS-CoV-2 RNA. However, our data suggest that re-positive is not a relapse of COVID-19, and the risk of onward transmission is very low.
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影响因子：
6.1
作者：
Liu, Kui;Fang, Yuan-Yuan;Liu, Hui-Guo
通讯作者：
Liu, Hui-Guo
影响因子：
82.9
作者：
He, Xi;Lau, Eric H. Y.;Leung, Gabriel M.
通讯作者：
Leung, Gabriel M.
DOI：
10.1097/im9.0000000000000022
发表时间：
2020-04-17
期刊：
Infectious Microbes & Diseases
影响因子：
--
作者：
He Y
通讯作者：
He Y
中国武汉市 138 例 2019 新型冠状病毒感染肺炎住院患者的临床特征。
影响因子：
120.7
作者：
Wang, Dawei;Hu, Bo;Peng, Zhiyong
通讯作者：
Peng, Zhiyong
DOI：
10.1164/rccm.201706-1172oc
发表时间：
2018-03-15
影响因子：
24.7
作者：
Arabi, Yaseen M.;Mandourah, Yasser;Fowler, Robert A.
通讯作者：
Fowler, Robert A.