Age-related attenuation of conduit artery blood flow response to passive heating differs between the arm and leg
Age-related attenuation of conduit artery blood flow response to passive heating differs between the arm and leg
复制标题
手臂和腿部对被动加热的导管动脉血流反应与年龄相关的衰减有所不同
DOI：
10.1007/s00421-018-3953-5
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发表时间：
2018
影响因子：
3
通讯作者：
Inoue Yoshimitsu
中科院分区：
文献类型：
--
作者：
Oue Anna;Asashima Chie;Oizumi Risa;Ichinose-Kuwahara Tomoko;Kondo Narihiko;Inoue Yoshimitsu
研究目的：为什么随着年龄的增长，热损失反应的衰减是从下肢开始的，目前还知之甚少。本研究旨在确定被动加热是否会导致导管肱动脉和股动脉之间血流（BF）反应的年龄相关性降低和肢体特异性差异，这与上下肢之间的皮肤血管传导性（CVC）差异有关。超声测量肱动脉和股动脉中的BF，并在小腿浸泡在42 °C热水中期间评估前臂和大腿中的CVC结果两个年龄组被动加热结束时肱动脉血流量增加的幅度相似老年组股动脉内径为119 ± 4%，青年组为166 ± 11%，P < 0.01。前臂CVC的增加在年龄组间相似（老年组：356 ± 50%;青年组：308 ± 46%），而大腿CVC在年龄组显著低于青年组（303 ± 33%vs.427 ± 51%，P < 0.05）。这些结果分别对应于肱动脉和股动脉的BF反应。结论这些结果表明，与年龄相关的减少和肢体特异性差异也发生在手臂和腿部的管道动脉，这可能与前臂和大腿之间的CVC的不同减少。
PurposeLittle is known about why the attenuation of heat loss responses with aging begins in the lower limbs. This study sought to determine whether passive heating causes the age-related decrease and limb-specific difference of blood flow (BF) responses between conduit brachial and femoral arteries, which are related to differences of cutaneous vascular conductance (CVC) between the upper and lower limbs.MethodIn 15 older and 12 younger males, BF in the brachial and femoral arteries was ultrasonically measured and CVC in the forearm and thigh was assessed during lower leg immersion in hot water at 42 °C (ambient temperature: 30 °C, relative humidity: 45%) for 40 min.ResultsThe increased BF of brachial artery at the end of passive heating was similar between both age groups (older: 140 ± 4%; younger: 146 ± 11%), while that of femoral artery was smaller in older than younger group (119 ± 4% vs. 166 ± 11%,P< 0.01). Moreover, the increased CVC in the forearm was similar between the age groups (older: 356 ± 50%; younger: 308 ± 46%), although CVC in the thigh was significantly lower in older than younger group (303 ± 33% vs. 427 ± 51%,P< 0.05). These results corresponded to the BF responses of the brachial and femoral arteries, respectively.ConclusionThese results indicate that age-related decrease and limb-specific difference occur also in conduit arteries of arm and leg, which might be related to the different reduction in CVC between forearm and thigh.
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DOI：
10.1152/japplphysiol.00729.2015
发表时间：
2015
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
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影响因子：
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DOI：
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影响因子：
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影响因子：
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DOI：
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影响因子：
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通讯作者：
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