Synthesis of functionalized nitroarylmagnesium halides via an iodine-magnesium exchange.
Synthesis of functionalized nitroarylmagnesium halides via an iodine-magnesium exchange.
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通过碘-镁交换合成官能化硝基芳基镁卤化物。
DOI：
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发表时间：
2005
影响因子：
3.6
通讯作者：
P. Knochel
中科院分区：
文献类型：
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作者：
Ioannis Sapountzis;H. Dube;R. Lewis;N. Gommermann;P. Knochel
[反应：各种硝基取代的芳基和杂芳基碘化物在用PhMgCl处理时发生碘-镁交换反应，产生含硝基的镁有机金属化合物。这些格氏试剂在低于-40 ° C的温度下显示出优异的稳定性，并且不进行电子转移反应。它们与各种亲电试剂发生预期的反应。
[reaction: see text] Various nitro-substituted aryl and heteroaryl iodides undergo an iodine-magnesium exchange reaction when treated with PhMgCl leading to nitro-containing magnesium organometallics. These Grignard reagents display an excellent stability at temperatures below -40 degrees C and do not undergo electron-transfer reactions. They react as expected with various electrophiles.