Ir-catalysed allylic substitution: mechanistic aspects and asymmetric synthesis with phosphorus amidites as ligands
Ir-catalysed allylic substitution: mechanistic aspects and asymmetric synthesis with phosphorus amidites as ligands
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DOI：
10.1039/a900864k
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发表时间：
1999-04-21
影响因子：
4.9
通讯作者：
Helmchen, G
中科院分区：
文献类型：
--
作者：
Bartels, B;Helmchen, G
使用 P(OPh)(3) 作为配体，对映体富集的单取代烯丙基乙酸酯进行 Ir 催化烯丙基烷基化，构型保留率高达 79%；进一步的证据支持σ-烯丙基配合物作为中间体的假设，并且以磷酰胺作为配体实现非手性或外消旋底物的不对称烯丙基烷基化中的高区域和对映选择性。
Ir-catalysed allylic alkylations of enantiomerically enriched monosubstituted allylic acetates proceed with up to 79% retention of configuration using P(OPh)(3) as ligand; further evidence supports the assumption of sigma-allyl complexes as intermediates, and high regio- and enantioselectivity in asymmetric allylic alkylations of achiral or racemic substrates is achieved with phosphorus amidites as ligands.