Anesthesia Neurotoxicity in the Developing Brain Basic Studies Relevant for Neonatal or Perinatal Medicine
Anesthesia Neurotoxicity in the Developing Brain Basic Studies Relevant for Neonatal or Perinatal Medicine
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DOI：
10.1016/j.clp.2019.08.002
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发表时间：
2019-12-01
影响因子：
2.1
通讯作者：
Disma, Nicola
中科院分区：
文献类型：
--
作者：
Clausen, Nicola Groes;Hansen, Tom G.;Disma, Nicola
早产儿的诊断和侵入性手术可能需要全身麻醉。全身麻醉剂会干扰未成熟动物大脑的发育。细胞凋亡加速、突触发生障碍和细胞结构被怀疑是这种现象的基础机制。这对人类的影响尚不清楚。本文介绍了目前被怀疑的麻醉性神经毒性的机制，并阐述了将动物研究结果转化为人类的困难。伦理方面的考虑限制了在人类新生儿身上进行这样的实验，但使用动物模型仍然被认为是可行的。大脑发育的脆弱时期需要进一步识别，神经毒性和神经保护干预也是如此。
Diagnostic and invasive procedures in premature infants may require general anesthesia. General anesthetics interfere with the development of the immature animal brain. Accelerated apoptosis, disturbed synaptogenesis, and cytoarchitecture are among the mechanisms suspected to underlie this phenomenon. The implications for humans are unknown. This article presents current suspected mechanisms of anesthesia-induced neurotoxicity and elaborates on the difficulties in translating results from animal research to human. Ethical considerations limit the conduct of such experiments in human neonates, but the use of animal models is still considered feasible. Vulnerable periods in brain development need further identification as do neurotoxic and neuroprotective interventions.