Intellectual awareness of naming abilities in people with chronic post-stroke aphasia.
Intellectual awareness of naming abilities in people with chronic post-stroke aphasia.
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DOI：
10.1016/j.neuropsychologia.2021.107961
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发表时间：
2021-09-17
期刊：
影响因子：
2.6
通讯作者：
Turkeltaub PE
中科院分区：
文献类型：
--
作者：
van der Stelt CM;Fama ME;Mccall JD;Snider SF;Turkeltaub PE
病感失认症，或普遍缺乏自我意识，经常出现在神经损伤后，并可能导致不良的功能结果。在中风后失语症中，智力意识的具体现象，即对自身功能受损的认识尚未得到广泛研究。我们的目的是通过比较脑卒中幸存者的失忆自我报告与客观命名表现和检查病变部位来确定智力意识的行为和神经相关性。53名没有严重理解缺陷的慢性失语症患者对自己的命名能力进行了评分，并完成了一系列行为测试。我们计算了参与者自我评价的可靠性和准确性，然后检查了智力意识差与言语、语言和认知测量的关系。我们使用支持向量回归病变症状映射（SVR-LSM）来确定与受损和保留的智力意识相关的病变位置。参与者自我评价的可靠性和准确性各不相同。智力意识差与依赖语义的任务的表现下降有关。我们的SVR-LSM结果表明，额下前部病变与意识差有关，而颞上中部病变与意识保留有关。在无阈值的病变-症状图中，前后梯度是明显的。虽然许多慢性失语症患者和相对完整的理解能力可以准确可靠地报告他们的失语症的严重程度，但其他人高估、低估或不一致地估计他们的命名能力。临床医生在使用自评量表时应该考虑到这一点，特别是当语义缺陷或前额下病变存在时。连续多天进行自我评定可能有助于检查患者感知的可靠性。
Anosognosia, or general lack of self-awareness, is often present following neurological injury and can result in poor functional outcomes. The specific phenomenon of intellectual awareness, the knowledge that a function is impaired in oneself, has not been widely studied in post-stroke aphasia. We aim to identify behavioral and neural correlates of intellectual awareness by comparing stroke survivors’ self-reports of anomia to objective naming performance and examining lesion sites. Fifty-three participants with chronic aphasia without severe comprehension deficits rated their naming ability and completed a battery of behavioral tests. We calculated the reliability and accuracy of participant self-ratings, then examined the relationship of poor intellectual awareness to speech, language, and cognitive measures. We used support vector regression lesion-symptom mapping (SVR-LSM) to determine lesion locations associated with impaired and preserved intellectual awareness. Reliability and accuracy of self-ratings varied across the participants. Poor intellectual awareness was associated with reduced performance on tasks that rely on semantics. Our SVR-LSM results demonstrated that anterior inferior frontal lesions were associated with poor awareness, while mid-superior temporal lesions were associated with preserved awareness. An anterior-posterior gradient was evident in the unthresholded lesion-symptom maps. While many people with chronic aphasia and relatively intact comprehension can accurately and reliably report the severity of their anomia, others overestimate, underestimate, or inconsistently estimate their naming abilities. Clinicians should consider this when administering self-rating scales, particularly when semantic deficits or anterior inferior frontal lesions are present. Administering self-ratings on multiple days may be useful to check the reliability of patient perceptions.
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影响因子：
2.4
作者：
Fama, Mackenzie E.;Henderson, Mary P.;Turkeltaub, Peter E.
通讯作者：
Turkeltaub, Peter E.
DOI：
10.1093/brain/awu286
发表时间：
2014-12
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Butler RA;Lambon Ralph MA;Woollams AM
通讯作者：
Woollams AM
影响因子：
4.8
作者：
DeMarco AT;Turkeltaub PE
通讯作者：
Turkeltaub PE
影响因子：
3.2
作者：
Fujimoto H;Matsuoka T;Kato Y;Shibata K;Nakamura K;Yamada K;Narumoto J
通讯作者：
Narumoto J
影响因子：
2
作者：
Allen CM;Martin RC;Martin N
通讯作者：
Martin N