Genotypes of Pneumocystis jiroveci isolates obtained in Harare, Zimbabwe, and London, United Kingdom
Genotypes of Pneumocystis jiroveci isolates obtained in Harare, Zimbabwe, and London, United Kingdom
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DOI：
10.1128/aac.47.12.3979-3981.2003
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发表时间：
2003-12-01
影响因子：
4.9
通讯作者：
Wakefield, AE
中科院分区：
文献类型：
--
作者：
Miller, RF;Lindley, AR;Wakefield, AE
对来自英国伦敦和津巴布韦哈拉雷的暴露于磺胺和未暴露于磺胺的患者分离的吉罗维西肺孢子虫进行了基因分型。在二氢翼酸合成酶(DHPS)基因座上，有证据表明磺胺类药物暴露带来了选择压力，当选择压力消失或消除时，DHPS基因比例发生反转。
Isolates of Pneumocystis jiroveci from sulfa-exposed and nonexposed patients from London, United Kingdom, and Harare, Zimbabwe, were genotyped. At the dihydropteroate synthase (DHPS) locus, there was evidence of selection pressure from sulfa drug exposure, and reversal of DHPS genotype ratios occurred when selection pressure was absent or was removed.