Nutrition and Toxicity Modulation: the Impact of Animal Body Weight On Study Outcome
Nutrition and Toxicity Modulation: the Impact of Animal Body Weight On Study Outcome
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营养和毒性调节：动物体重对研究结果的影响
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
R. Hart
中科院分区：
文献类型：
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作者：
W. Allaben;R. Hart
生物医学研究界开发并使用了各种啮齿动物物种和品系，以确定和了解疾病的生物机制，评估食品添加剂和药物的安全性，并评估化学品的毒性和/或致癌作用。在20世纪60年代，美国国家癌症研究所（NCI）开发了一个大规模的化学测试计划，以筛选潜在的致癌物质（生物测定计划）。1981年，生物测定计划被转移到新成立的国家毒理学计划（NTP）。从那时起，随着美国食品药品监督管理局（FDA）药物非临床研究质量管理规范（GLP）的建立，进行慢性毒性和致癌性研究的标准方案已经得到了完善。尽管如此，在过去的二十年里，变异性一直在稳步增加，
The biomedical research community has developed and used various rodent animal species and strains to identify and understand the biological mechanisms of disease, to assess the safety of food additives and drugs, and to evaluate the toxic and/or carcinogenic effects of chemicals. During the 1960s, a large-scale chemical testing program was developed by the National Cancer Institute (NCI) to screen potential cancer-causing substances (Bioassay Program). In 1981, the Bioassay Program was transferred to the newly established National Toxicology Program (NTP). Since that time, and with the establishment of Food and Drug Administration’s (FDA) Good Laboratory Practices Guidelines (GLP), standard protocols for conducting chronic toxicity and carcinogenicity studies have been refined. Nevertheless, over the last two decades, there has been a steady increase in variability, a decrease