THE SWITCH MECHANISM AND THE BIPOLAR UNIPOLAR DICHOTOMY
THE SWITCH MECHANISM AND THE BIPOLAR UNIPOLAR DICHOTOMY
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DOI：
10.1192/bjp.154.1.48
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发表时间：
1989-01-01
影响因子：
10.5
通讯作者：
REYNOLDS, EH
中科院分区：
文献类型：
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作者：
CARNEY, MWP;CHARY, TKN;REYNOLDS, EH
在对 29 名患者进行静脉注射和口服 S-腺苷甲硫氨酸 (SAM) 的开放试验以及静脉注射 SAM 的安慰剂对照试验中，25 名患者接受了 SAM，4 名患者接受了安慰剂（27 个疗程的 SAM，其中两名患者各接受了两次试验）。 11 名双相情感障碍患者（均接受 SAM 治疗）中有 9 名转变为情绪升高状态（轻躁狂、躁狂和欣快感），另外 2 名患者没有反应。六名内源性单相情感障碍患者有所改善，五名则没有。没有非内源性患者或安慰剂患者的反应持续超过 14 天。没有单相情感障碍患者情绪变得高涨。在 11 项 (38%) 试验中，9 名 (33%) 患者从抑郁转变为兴高采烈。来自八名患者脑脊液的生化数据表明，应进一步探讨多巴胺能系统的作用。
During open trials of intravenous and oral S-adenosyl methionine (SAM) and a placebo-controlled trial of intravenous SAM in 29 patients, 25 patients had SAM and four had placebo (27 courses of SAM, two of the patients receiving two trials apiece). Nine of 11 bipolar patients (all SAM-treated) switched into elevated mood state (hypomania, mania and euphoria) and two did not respond. Six endogenous unipolar patients improved and five did not. No non-endogenous patient or placebo patient responded for more than 14 days. No unipolar patient switched into eleated mood. In eleven (38%) trials and nine (33%) patients there was a switch from depression to elation. Biochemical data from the cerebrospinal fluid of eight patients suggesting that the role of the dopaminergic system should be further explored.