Maintenance of wakefulness test and multiple sleep latency test. Measurement of different abilities in patients with sleep disorders.
Maintenance of wakefulness test and multiple sleep latency test. Measurement of different abilities in patients with sleep disorders.
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DOI：
10.1378/chest.101.4.898
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发表时间：
1992-04
期刊：
影响因子：
9.6
通讯作者：
R. Sangal;Larry Thomas;Merrill M. Mitler
中科院分区：
文献类型：
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作者：
R. Sangal;Larry Thomas;Merrill M. Mitler
在同一天对258例临床表现需要评估过度嗜睡的连续患者进行多次睡眠潜伏期试验和觉醒维持试验。虽然MPERT是评估白天过度嗜睡的标准测试，但当白天警觉性的评估是主要目标时，MWT可能比MPERT具有一些临床优势。为了进一步探讨警觉性和嗜睡之间的关系，我们对MWT和MPEST之间的相似性，差异性和相关性进行了深入的分析。本研究的结果表明，MPEST和MWT之间的相关系数（r = 0.41），虽然统计学上显着，占不到17%的变异性之间的两个测试。因子分析表明，两个因素，警觉性和困倦，占所有方差的91%。我们的数据表明，患有过度嗜睡的可诊断疾病的患者可能在两项测试中不一致（例如，MPERT睡眠潜伏期较低，但MWT睡眠潜伏期较高）。具体来说，我们发现，一些MPEG4评分异常低的患者在MWT上被要求保持清醒时能够保持清醒，相反，一些在MWT上被要求保持清醒时未能保持清醒的患者在MPEG4上无法迅速入睡。我们的结论是MWT和MPEG4测量不同的能力，MWT可能是一个有用的辅助日间测试在许多临床情况下。
The multiple sleep latency test and the maintenance of wakefulness test were administered on the same day to 258 consecutive patients whose clinical presentation required evaluation for excessive sleepiness. While the MSLT is the standard test for assessing excessive daytime sleepiness, the MWT may have some clinical advantage over the MSLT when the assessment of daytime alertness is the primary goal. To explore further the relationship between alertness and sleepiness, we have conducted a thorough analysis of the similarities, differences, and correlations between MWT and MSLT. The results of this study show that the coefficient of correlation between MSLT and MWT (r = 0.41), although statistically significant, accounts for less than 17 percent of the variability between the two tests. Factor analysis suggests that two factors, alertness and sleepiness, account for 91 percent of all variance. Our data demonstrate that patients with diagnosable disorders of excessive somnolence may be discordant on the two tests (eg, having low sleep latency on MSLT but high sleep latency on MWT). Specifically, we found that some patients with abnormally low MSLT scores were able to stay awake when asked to do so on the MWT, and conversely, some patients who failed to stay awake when asked to do so on the MWT were unable to fall asleep quickly on the MSLT. We conclude that the MWT and MSLT measure different abilities and that the MWT may be a useful adjuvant daytime test in many clinical situations.