Experience of a "slip" among alcoholics treated with naltrexone or placebo.
Experience of a "slip" among alcoholics treated with naltrexone or placebo.
复制标题
用纳曲酮或安慰剂治疗的酗酒者的“失误”经历。
DOI：
10.1176/ajp.153.2.281
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Rounsaville,BJ
中科院分区：
文献类型：
--
作者：
O'Malley,SS;Jaffe,AJ;Rode,S;Rounsaville,BJ
目的本研究验证了纳曲酮通过改变初始饮酒和酒精诱导的渴望的强化作用来降低酗酒者复发率的假设。方法16名接受纳曲酮治疗的酗酒患者和27名接受安慰剂治疗的酗酒患者参加了一项12-一项为期一周的临床试验回顾性地报告了他们对首次饮酒的主观反应以及他们终止饮酒的原因饮酒事件。ResultsThese研究结果支持这一假设，即纳洛酮的中枢效应是酒精诱导的渴求的修改。
ObjectiveThis study tested the hypothesis that naltrexone reduces relapse rates among alcoholics by modifying the reinforcing effects of initial alcohol consumption and alcohol-induced craving.MethodSixteen alcoholic patients treated with naltrexone and 27 treated with placebo who participated in a 12-week clinical trial reported retrospectively on their subjective responses to their first episode of a lapse into alcohol consumption and on their reasons for terminating the drinking episode.ResultsCompared to the subjects who received placebo, the subjects who received naltrexone reported lower levels of craving for alcohol and were more likely to give reasons for terminating drinking that were consistent with decreased incentive to drink.ConclusionsThese findings support the hypothesis that a central effect of naltrexone is the modification of alcohol-induced craving.
纳曲酮对酗酒者酒精“高”的影响。
DOI：
10.1176/ajp.152.4.613
发表时间：
1995
期刊：
The American journal of psychiatry.
影响因子：
--
作者：
Volpicelli,JR;Watson,NT;King,AC;Sherman,CE;O'Brien,CP
通讯作者：
O'Brien,CP
影响因子：
--
作者：
O'Malley,SS;Jaffe,AJ;Chang,G;Schottenfeld,RS;Meyer,RE;Rounsaville,B
通讯作者：
Rounsaville,B
影响因子：
--
作者：
Volpicelli,JR;Alterman,AI;Hayashida,M;O'Brien,CP
通讯作者：
O'Brien,CP