Two new noroleanane-type triterpenoid saponins from the stems of Stauntonia chinensis
Two new noroleanane-type triterpenoid saponins from the stems of Stauntonia chinensis
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DOI：
10.1080/14786419.2018.1470515
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发表时间：
2019-05-03
影响因子：
2.2
通讯作者：
Wang, Dong
中科院分区：
文献类型：
--
作者：
Feng, Tong-Tong;Fu, Hui-Zheng;Wang, Dong
两种新的降油烷型三萜皂苷，3β,20α,24-三羟基-29-降油酸-12-en-28-oic酸24-O-β-L-吡喃岩藻糖基-(1 -> 2)-[β-D-吡喃木糖基-(1 -> 3)]-β-D-吡喃葡萄糖苷(1)和3β,20 从野木瓜的茎中分离出α,24-三羟基-29-降咯烷-12-en-28-oic酸24-O-β-D-吡喃葡萄糖基-(1 -> 2)-[α-L-阿拉伯吡喃糖基-(1 -> 3)]-β-D-吡喃葡萄糖苷(2)以及三种已知化合物， Brachyantheraoside B-2 (3)、eupteleasaponin x2167； (4) 和fargoside B (5)。通过光谱和化学方法阐明了它们的结构。针对五种人类肿瘤细胞系（HCT-116、HepG2、BGC-823、NCI-H1650 和 A2780）评估了化合物 1 和 2 的细胞毒活性。化合物1和2对测试的细胞系表现出中等的细胞毒活性，IC50值范围为12.71至32.04μM。[图表]。
Two new noroleanane-type triterpenoid saponins, 3 beta,20 alpha,24-trihydroxy-29-norolean-12-en-28-oic acid 24-O-beta-L-fucopyranosyl-(1 -> 2)-[beta-D-xylopyranosyl-(1 -> 3)]-beta-D-glucopyranoside (1) and 3 beta,20 alpha,24-trihydroxy-29-norolean-12-en-28-oic acid 24-O-beta-D-glucopyranosyl-(1 -> 2)-[alpha-L-arabinopyranosyl-(1 -> 3)]-beta-D-glucopyranoside (2) were isolated from the stems of Stauntonia chinensis DC., together with three known compounds, brachyantheraoside B-2 (3), eupteleasaponin x2167; (4) and fargoside B (5). Their structures were elucidated by spectroscopic and chemical methods. The cytotoxic activities of compounds 1 and 2 were evaluated against five human tumor cell lines (HCT-116, HepG2, BGC-823, NCI-H1650, and A2780). Compounds 1 and 2 showed moderate cytotoxic activities toward the tested cell lines with IC50 values ranging from 12.71 to 32.04 mu M.[GRAPHICS].