Prejunctional cholinergic modulation of adrenergic neurotransmission in the cardiovascular system.
Prejunctional cholinergic modulation of adrenergic neurotransmission in the cardiovascular system.
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心血管系统中肾上腺素能神经传递的交界前胆碱能调节。
DOI：
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发表时间：
1980
影响因子：
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通讯作者：
M. N. Levy
中科院分区：
文献类型：
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作者：
P. Vanhoutte;M. N. Levy
在心脏和血管壁中，复杂的肾上腺素能-胆碱能相互作用既发生在自主神经末梢水平的连接前，也发生在反应细胞本身水平的连接后。主要的prejunctional相互作用似乎是从肾上腺素能神经末梢释放的乙酰胆碱从附近的胆碱能神经末梢释放的去甲肾上腺素的抑制。这种抑制作用由位于节后交感神经末梢上的毒蕈碱受体介导。因此，乙酰胆碱对心脏和血管组织的抑制作用部分是通过胆碱能神经递质对心脏和血管肌肉细胞的直接影响，部分是通过对交感神经传递的间接影响来实现的。
In the heart and in the blood vessel walls, complex adrenergic-cholinergic interactions occur both prejunctionally, at the level of the autonomic nerve terminals, and postjunctionally, at the level of the responding cells themselves. The principal prejunctional interaction appears to be an inhibition of the release of norepinephrine from adrenergic nerve terminals by the acetylcholine liberated from nearby cholinergic nerve endings. This inhibitory effect is mediated by muscarinic receptors located on the postganglionic sympathetic nerve terminals. The inhibitory effect of acetylcholine on cardiac and vascular tissues are therefore achieved in part by a direct influence of the cholinergic neurotransmitter on the cardiac and vascular muscle cells, and in part by an indirect influence on sympathetic neurotransmission.