Dynamic changes in inhibin messenger RNAs in rat ovarian follicles during the reproductive cycle.
Dynamic changes in inhibin messenger RNAs in rat ovarian follicles during the reproductive cycle.
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生殖周期期间大鼠卵泡中抑制素信使 RNA 的动态变化。
DOI：
10.1126/science.3125611
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Mayo,KE
中科院分区：
文献类型：
--
作者：
Woodruff,TK;D'Agostino,J;Schwartz,NB;Mayo,KE
随着卵泡的成熟、排卵和形成黄体，卵泡的形态和功能发生了巨大的变化。各种类固醇和多肽激素影响这些过程，卵巢反过来产生内分泌调节的特定荷尔蒙信号。抑制素就是这样的信号之一，它是一种异源二聚体蛋白，可以抑制垂体促性腺激素细胞分泌卵泡刺激素。用大鼠抑制素互补核酸探针检测了周期动物卵巢中抑制素α和βA亚单位信使RNA的水平和分布。在卵泡发育成熟过程中，抑制素信使RNA的积累发生了显著的动态变化。
The alterations in morphology and function of the ovarian follicle as it matures, ovulates, and becomes a corpus luteum are dramatic. A variety of steroid and polypeptide hormones influence these processes, and the ovary in turn produces specific hormonal signals for endocrine regulation. One such signal is inhibin, a heterodimeric protein that suppresses the secretion of follicle-stimulating hormone from pituitary gonadotrophs. Rat inhibin complementary DNA probes have been used to examine the levels and distribution of inhibin α- and βA-subunit messenger RNAs in the ovaries of cycling animals. Striking, dynamic changes have been found in inhibin messenger RNA accumulation during the developmental maturation of the ovarian follicle.