Expression of Myc target gene mina53 in subtypes of human lymphoma.
Expression of Myc target gene mina53 in subtypes of human lymphoma.
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DOI：
10.3892/or.18.4.841
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发表时间：
2007-10
期刊：
影响因子：
4.2
通讯作者：
K. Teye;N. Arima;Yasuhiro Nakamura;K. Sakamoto;E. Sueoka;H. Kimura;M. Tsuneoka
中科院分区：
文献类型：
--
作者：
K. Teye;N. Arima;Yasuhiro Nakamura;K. Sakamoto;E. Sueoka;H. Kimura;M. Tsuneoka
Mina 53（mina）是一个由癌基因c-myc直接诱导的基因。在>80%的结肠癌和食管鳞状细胞癌（ESCC）中发现Mina 53蛋白的高表达。Mina 53高表达的患者生存期较短，提示Mina 53的预后有用性。我们研究了Mina 53在淋巴瘤亚型中的表达，以检查其诊断意义及其在淋巴瘤发生中的可能作用。应用抗Mina 53单克隆抗体对28例淋巴瘤和4例非肿瘤组织进行免疫组化染色。Mina 53表达与c-Myc表达在淋巴瘤中相关性良好，表明c-Myc也是mina 53表达在淋巴瘤中的控制因子。虽然Mina 53和c-Myc在淋巴瘤中的表达与结肠癌和食管鳞癌相比较少，但在Burkitt样淋巴瘤（1/1）、霍奇金淋巴瘤（3/5）、弥漫性大B细胞淋巴瘤（5/13）、滤泡性淋巴瘤向DLBCL转变（1/2）、滤泡性淋巴瘤（0/4）和T细胞淋巴瘤（0/3）均为阴性。数据分析表明Mina 53在侵袭型B细胞淋巴瘤中频繁表达。为了获得更多关于Mina 53在DLBCL中表达的信息，DLBCL最常发生在淋巴瘤中，我们分析了另外21个DLBCL标本中Mina 53的表达，这些标本的分期比上述的更晚期。Mina 53蛋白表达水平与国际预后指数（IPI）呈显著正相关（r=0.477，P=0.0275）。值得注意的是，在该组中，Mina 53表达与c-Myc表达不相关，表明除了c-Myc之外的其他因子在很大程度上影响晚期DLBCL中Mina 53的表达。这些结果表明，虽然Mina 53的表达在一般的淋巴瘤中并不突出，但它可能与B细胞淋巴瘤的肿瘤进展有关。
Mina53 (mina) was identified as a gene, which is directly induced by the oncogene c-myc. Elevated expression of Mina53 protein was found in >80% of colon cancer and esophageal squamous cell carcinoma (ESCC). Patients with high expression of Mina53 had shorter survival, suggesting the prognostic usefulness of Mina53. We studied Mina53 expression in lymphoma subtypes to examine its diagnostic significance and its possible role in lymphoma-genesis. Surgical cases of 28 lymphoma and 4 non-neoplastic tissues were stained immunochemically using anti-Mina53 monoclonal antibody. Mina53 expression correlated well with c-Myc expression in lymphoma, suggesting that c-Myc is a controlling factor for mina53 expression also in lymphomas. Although the expression of Mina53 as well as c-Myc was less frequent in lymphoma compared with those of colon and ESCC, increased expression of Mina53 was found in Burkitt-like lymphoma (1/1), Hodgkin's lymphoma (3/5), diffuse large B cell lymphoma (DLBCL) (5/13), lymphomas with a transition from follicular to DLBCL (1/2), with none in follicular (0/4) and T cell lymphoma (0/3). Analyses of the data suggested that Mina53 was frequently expressed in aggressive types of B cell lymphoma. To get more information about the expression of Mina53 in DLBCL, which most frequently occurs among lymphomas, we analyzed the expression of Mina53 in another 21 DLBCL specimens, which were in more advanced stages than those described above. The expression level of Mina53 correlated to the international prognostic index (IPI) values with statistical significance (r=0.477, P=0.0275). Notably, in this group, Mina53 expression did not correlate with c-Myc expression, suggesting that other factor(s) besides c-Myc largely affect the expression of Mina53 in advanced DLBCL. These results suggest that although Mina53 expression is not prominent in lymphoma in general, it may be related to tumor progression of B cell lymphoma.