Prenatal and adult stress interplay - behavioral implications
Prenatal and adult stress interplay - behavioral implications
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DOI：
10.1016/j.brainres.2010.01.008
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发表时间：
2010-03-12
期刊：
影响因子：
2.9
通讯作者：
Hougaard, K. S.
中科院分区：
文献类型：
--
作者：
Kjaer, S. L.;Wegener, G.;Hougaard, K. S.
成年人行为的起源和精神疾病的可能发病机制仍然是一个谜，但广泛的研究表明，基因和环境的相互作用对成年人的表型起着至关重要的作用。易感性的差异可能由早期经历和基因组变量单独或组合引起。已经证明，在患有几种精神疾病的患者中，声惊吓反应（ASR）会发生改变，这种变化可能是由继发于创伤事件的慢性唤醒引起的持续敏化引起的。目前的工作假设，一个单一的厌恶程序将诱导长期过度活跃的HPA轴的大鼠，已经成为脆弱的产前压力，从而改变反应的ASR，产前压力是通过母亲妊娠暴露于慢性轻度应激（CMS）。在3个月大时，通过压力程序对后代进行血液采样，随后在声学惊吓范例中进行测试。产前CMS强烈减少前脉冲抑制（PPI），而产后血液采样下的限制一般增加PPI。我们的数据表明，产前和产后的压力事件之间的相互作用，而且这种相互作用是复杂的，可能会影响PPI和基础惊吓之间的相互作用。我们的研究结果表明，可以追溯到早期发展的情况可能会影响成年生活行为，并在此基础上，我们提出了一个新的理论阈值诱导的压力反应在ASR测试，这影响PPI或基础惊吓反应是否会受到影响。(C)2010 Elsevier B.V.保留所有权利。
The origin of adult behavior and the possible pathogenesis of psychiatric disorders remain elusive, but extensive research indicates that interaction of genes and environment play a crucial role for adult phenotype. Differences in susceptibility may arise by earlier experiences and genomic variables, either alone or in combination. The acoustic startle response (ASR) has been shown to be altered in patients with several psychiatric diseases, a change that could result from a persistent sensitization caused by chronic arousal secondary to a traumatic incident. The current work hypothesized that a single aversive procedure would induce long-term hyperactivity in the HPA-axis of rats that had become vulnerable by prenatal stress, and thereby change reactivity in the ASR, Prenatal stress was achieved by maternal gestational exposure to Chronic Mild Stress (CMS). At age 3 months, the offspring were blood sampled by a stressful procedure, and subsequently tested in the acoustic startle paradigm. Prenatal CMS strongly reduced prepulse inhibition (PPI) whereas postnatal blood sampling under restraint generally increased PPI. Our data demonstrate inter-play between pre- and postnatal stressful events, but also that this interaction is complex and could influence the interplay between PPI and basal startle. Our results suggest that circumstances dating back to early development may have implications for adult life behavior, and based on this we propose a new theory of a threshold in the induction of a stress response in the ASR test, which influences whether the PPI or basal startle response will be affected. (C) 2010 Elsevier B.V. All rights reserved.