Assessment of response to neoadjuvant radiochemotherapy with F-18 FLT and F-18 FDG PET/CT in patients with rectal cancer.
Assessment of response to neoadjuvant radiochemotherapy with F-18 FLT and F-18 FDG PET/CT in patients with rectal cancer.
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DOI：
10.1007/s12149-014-0938-2
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发表时间：
2015-04
影响因子：
2.6
通讯作者：
Pirich C
中科院分区：
文献类型：
--
作者：
Rendl G;Rettenbacher L;Holzmannhofer J;Datz L;Hauser-Kronberger C;Fastner G;Öfner D;Sedlmayer F;Pirich C
直肠癌患者新辅助放化疗（RCT）前后2-脱氧-2-[18 F]氟-d-葡萄糖（F-18 FDG）和3′-脱氧-3 ′-[18 F]氟胸苷（F-18 FLT）成像与手术获得的组织病理学和免疫组织化学的比较。本前瞻性研究纳入了20例连续患者（15例男性，5例女性），平均年龄为65 ± 10岁，平均随访时间为4.1 ± 0.8年。在组织病理学应答者（n = 8/20）中，治疗后F-18 FLT和F-18 FDG扫描分别为75%（n = 6）和38%（n = 3）阴性。F-18 FLT和F-18 FDG显像的平均反应指数（RI）分别为61.0% ± 14.0%和58.7% ± 14.6%。在F-18 FDG研究中，瘤周淋巴细胞浸润（CD 3阳性细胞）与治疗后SUVmax显著相关，但与F-18 FLT研究无关。F-18 FDG和F-18 FLT研究中的SUVmax在RCT后显著降低。阴性治疗后F-18 FLT研究确定了更多的组织病理学缓解者。
The comparison of 2-deoxy-2-[18F]fluoro-d-glucose (F-18 FDG) and 3′-deoxy-3′-[18F]fluorothymidine (F-18 FLT) imaging in patients with rectal cancer before and after neoadjuvant radiochemotherapy (RCT) in relation to histopathology and immunohistochemistry obtained from surgery. 20 consecutive patients (15 m, 5 f), mean age of 65 ± 10 years were included into this prospective study with a mean follow-up of 4.1 ± 0.8 years. Among histopathological responders (n = 8 out of 20), posttreatment F-18 FLT and F-18 FDG scans were negative in 75 % (n = 6) and 38 % (n = 3), respectively. The mean response index (RI) was 61.0 % ± 14.0 % for F-18 FLT and 58.7 % ± 14.6 % for F-18 FDG imaging. Peritumoral lymphocytic infiltration (CD3 positive cells) was significantly related to posttreatment SUVmax in F-18 FDG but not F-18 FLT studies. A significant decrease of SUVmax in F-18 FDG and F-18 FLT studies could be seen after RCT. Negative posttreatment F-18 FLT studies identified more histopathological responders.