In vivo tissue injury mapping using optical coherence tomography based methods.
In vivo tissue injury mapping using optical coherence tomography based methods.
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DOI：
10.1364/ao.54.006448
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发表时间：
2015-07-20
期刊：
影响因子：
1.9
通讯作者：
Wang RK
中科院分区：
文献类型：
--
作者：
Baran U;Li Y;Wang RK
损伤引起在组织内行进的光束的光学衰减系数的变化。我们报告了一种称为组织损伤映射（TIM）的方法，该方法利用非侵入性的体内光学相干断层扫描方法来生成光学衰减系数和损伤组织的微血管图。使用TIM，在中风期间小鼠大脑皮层中的梗塞区域的发展是可视化的。此外，我们展示了人类面部皮肤结构和微血管系统的变化，在痤疮病变的发展，从启动到疤痕。结果表明，TIM可用于通过实现组织结构和微血管变化的高分辨率检测来帮助表征和治疗各种疾病。
An injury causes changes in the optical attenuation coefficient of light beam travelling inside a tissue. We report a method called tissue injury mapping (TIM), which utilizes a non-invasive in vivo optical coherence tomography approach to generate optical attenuation coefficient and microvascular map of the injured tissue. Using TIM, the infarct region development in mouse cerebral cortex during stroke is visualized. Moreover, we demonstrate the changes in human facial skin structure and microvasculature during an acne lesion development from initiation to scarring. The results indicate that TIM may be used to aid in the characterization and the treatment of various diseases by enabling a high resolution detection of tissue structural and microvascular changes.