Human coronavirus ocurrence in different populations of Sao Paulo: a comprehensive nine-year study using a pancoronavirus RT-PCR assay
Human coronavirus ocurrence in different populations of Sao Paulo: a comprehensive nine-year study using a pancoronavirus RT-PCR assay
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DOI：
10.1590/s1517-83822013000100049
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发表时间：
2013-01-01
影响因子：
2.2
通讯作者：
Bellei, Nancy
中科院分区：
文献类型：
--
作者：
Cabeça, Tatiane K.;Passos, Ana Maria;Bellei, Nancy
人类冠状病毒(HCoV)被认为是与呼吸道疾病有关的最常见的呼吸道病毒之一。2002-2003年间，一种突发的人类冠状病毒被确定为严重急性呼吸综合征(SARS)流行的病原体。该疾病的严重性及其迅速传播要求在全世界人口中持续监测冠状病毒。巴西人群中感染HCoV的流行病学和临床数据很少，而且仅限于一组或两组患者。我们的研究旨在对2001-2010年间圣保罗不同表现为急性呼吸道感染(ARIS)的人群中HCoV的存在进行回顾性调查。本研究对一种新的潘科纳病毒进行了RT-PCR。在1,087份样本中，有126份(11.5%)检出冠状病毒。峰值检测频率在2002-2004年和2008-2009年期间观察到，2008年最高。心脏病儿童(24.6%)、干细胞移植患者(24.3%)和肾移植患者(20.2%)HCoV感染率较高。出现阳性病例时最常见的症状是鼻炎、咳嗽、发热和喘息，下呼吸道感染症状占总人数的12%，高危患者占27%。HCoV可能在有基础疾病的患者和移植患者中发挥重要作用。
Human coronaviruses (HCoVs) are considered one of the most common respiratory viruses associated with respiratory tract illnesses. An emergent human coronavirus was identified as the causal agent of an epidemic of severe acute respiratory syndrome (SARS) during 2002-2003. The severity of the disease combined with its rapid spread requires the continuous surveillance of coronaviruses in worldwide populations. Epidemiological and clinical data of HCoVs infectious in the Brazilian population are scarce and restricted to one or two groups of patients. Our study aimed to investigate retrospectively the presence of HCoVs in different populations of Sao Paulo presenting acute respiratory tract infections (ARIs) during the years of 2001-2010. A pancoronavirus RT-PCR was performed in this study. Coronaviruses were detected in 126 (11.5%) of 1,087 specimens. Peaks detection frequency was observed during 2002-2004 and 2008-2009, with the highest detection in 2008. The prevalence of HCoVs was higher among children with heart diseases (24.6%), patients under stem cell transplantation program (24.3%) and renal transplanted patients (20.2%). Coryza, cough and fever were the most common symptoms at presentation of positive cases and wheezing, a lower respiratory tract infection symptom was reported by 12% of the total, and 27% of high at-risk patients. HCoVs may have an important role among patients with underlying conditions and transplanted ones.