Evaluation of clinical markers of atherosclerosis in young and elderly Japanese adults
Evaluation of clinical markers of atherosclerosis in young and elderly Japanese adults
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DOI：
10.1515/cclm.2006.149
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发表时间：
2006-07-01
影响因子：
6.8
通讯作者：
Aoyagi, Kiyoshi
中科院分区：
文献类型：
--
作者：
Hara, Takanobu;Takamura, Noboru;Aoyagi, Kiyoshi
背景资料：为了能够在生命早期对动脉粥样硬化的发展采取预防措施，重要的是评估亚临床动脉粥样硬化的概况，特别是在年轻人中。方法：我们筛选了年轻人和老年人的血浆同型半胱氨酸水平、高敏C反应蛋白水平和颈动脉内膜中层厚度。结果：在年轻人和老年人中，血浆同型半胱氨酸和高敏C反应蛋白在女性中显着低于男性。高敏C反应蛋白在年轻人中显著低于老年人，同型半胱氨酸在年轻人中低于老年人（但不显著）。在年轻成人中，女性的平均颈动脉内膜中层厚度低于男性（但不显著）。在老年人中，女性的平均颈动脉内膜中层厚度显著低于男性。在男性和女性中，平均颈动脉内膜中层厚度显着较高的老年人比年轻adult.Conclusions：这些结果表明动脉粥样硬化标志物在年轻和老年日本成年人的基本配置文件。需要进一步的研究来评估在成年早期预防动脉粥样硬化的措施。
Background: In order to be able to take preventative measures early in life against the development of atherosclerosis, it is important to evaluate profiles of subclinical atherosclerosis, especially among young adults.Methods: We screened plasma homocysteine levels, highly sensitive C-reactive protein levels and carotid intima-media thickness in young and elderly adults.Results: Among both young and elderly adults, plasma homocysteine and highly sensitive C-reactive protein were significantly lower in females than in males. Highly sensitive C-reactive protein was significantly lower in young adults than in elderly adults, and homocysteine was lower ( but not significantly) in young adults than in elderly adults. Among young adults, mean carotid intima-media thickness was lower ( but not significantly) in females than in males. Among elderly adults, mean carotid intima-media thickness was significantly lower in females than in males. Among both males and females, mean carotid intima-media thickness was significantly higher in elderly adults than in young adults.Conclusions: These results demonstrate basic profiles of atherosclerosis markers in young and elderly Japanese adults. Further study is needed to evaluate measures developed for application in early adulthood to prevent atherosclerosis.