Significance of tumor necrosis factor microsatellite polymorphism in renal transplantation.
Significance of tumor necrosis factor microsatellite polymorphism in renal transplantation.
复制标题
肿瘤坏死因子微卫星多态性在肾移植中的意义
DOI：
10.1111/j.1399-0039.1997.tb02903.x
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
H. Takagi
中科院分区：
文献类型：
--
作者：
H. Asano;T. Kobayashi;K. Uchida;S. Hayashi;I. Yokoyama;H. Inoko;H. Takagi
肿瘤坏死因子（TNF）α的血浆水平在器官移植后的急性排斥反应期间升高。已发现TNF α产生的变化与TNF微卫星的多态性相关。因此，具有某种类型的TNF微卫星的移植受者可能是移植物排斥的高风险患者。本研究旨在探讨肿瘤坏死因子（TNF）微卫星多态性与急性移植排斥反应的关系。我们研究了两个微卫星TNFa和TNFd与肾移植后急性排斥反应的关系。在来自一名单倍型不匹配和一名DRB 1不匹配供体的189例初次活体相关肾移植中，我们分析了163名DNA可用于本研究的患者的TNF微卫星。TNFa 9微卫星等位基因的频率在排斥组中显著高于无排斥组。相反，与无排斥组相比，排斥组中TNFd4的频率显著降低。TNFa 9和TNFd4分别与HLA-B35和B44有很强的相关性。然而，TNF微卫星位点与急性排斥反应的关系比HLA-B更密切。提示TNF微卫星多态性分析可为预测移植后预后提供有用的信息。
Plasma levels of tumor necrosis factor (TNF) alpha are raised during acute rejection following organ transplantation. Variations in TNF alpha production have been found to be associated with the polymorphism of TNF microsatellite. Therefore, there is a possibility that a transplant recipient with some type of TNF microsatellite can be a high-risk patient of graft rejection. The purpose of this study was to examine whether TNF microsatellite polymorphism is related to acute allograft rejection. We investigated the relation of two microsatellites, TNFa and TNFd, to acute rejection after renal transplantation. Among 189 primary living-related renal transplantations from one haplotype-mismatched and one DRB1-mismatched donor, we analyzed TNF microsatellites of 163 patients whose DNA were available to this study. The frequency of the TNFa9 microsatellite allele was significantly higher in the rejection group compared to the rejection-free group. In contrast, the frequency of TNFd4 was significantly lower in the rejection group compared to the rejection-free group. TNFa9 and TNFd4 showed strong associations with HLA-B35 and B44, respectively. However, the TNF microsatellite locus was more closely related to acute rejection than HLA-B. It was suggested that the analysis of TNF microsatellite polymorphism can provide useful information in predicting prognosis after transplantation.