DOSE DEPENDENT REDUCTION OF GLUCOSE-UTILIZATION BY PENTOBARBITAL IN RAT-BRAIN
DOSE DEPENDENT REDUCTION OF GLUCOSE-UTILIZATION BY PENTOBARBITAL IN RAT-BRAIN
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DOI：
10.1161/01.str.9.1.12
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发表时间：
1978-01-01
期刊：
影响因子：
8.3
通讯作者：
OLDENDORF, WH
中科院分区：
文献类型：
--
作者：
CRANE, PD;BRAUN, LD;OLDENDORF, WH
用一种新的测定大鼠脑区葡萄糖利用率的方法，测定了戊巴比妥降低大脑皮层代谢活性的剂量依赖性。当大脑戊巴比妥钠水平超过50µg/g组织时，大脑皮质葡萄糖利用被抑制到控制率的44%的基础水平。这种作用的主要部分发生在大脑戊巴比妥10-20微克/克的范围内，这可以通过正常麻醉剂ip的1/5-1/10来实现。剂量。如果大脑代谢的抑制是先前报道的保护大脑免受缺血损伤的原因，这些数据表明，在急性脑缺血后，巴比妥酸剂量可显著降低大鼠的脑代谢率，这可能与人类的治疗相关。
A new method of determining the rate of glucose utilization in brain regions of individual rats was used to measure the dose dependency of the reduction of the metabolic activity of the cerebral cortex by pentobarbital. Cerebral cortical glucose utilization is depressed to a basal level of 44% of the control rate when cerebral pentobarbital levels exceed 50 .mu.g/g of tissue. The major portion of this effect occurs between the cerebral pentobarbital range of 10-20 .mu.g/g, which can be achieved by 1/5-1/10 the normal anesthetic i.p. dosage. If a depression of brain metabolism is responsible for the previously reported protection of the brain from ischemic damage, these data suggest a substantial reduction of brain metabolic rate is achieved in the rat at a barbiturate dosage which may be therapeutically relevant in the human after acute brain ischemia.