ABSENCE OF ANTIVIRAL ACTIVITY IN RECOMBINANT B-CELL STIMULATORY FACTOR-II (BSF-2)
ABSENCE OF ANTIVIRAL ACTIVITY IN RECOMBINANT B-CELL STIMULATORY FACTOR-II (BSF-2)
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DOI：
10.1016/0165-2478(88)90099-5
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发表时间：
1988-01-01
影响因子：
4.4
通讯作者：
KISHIMOTO, T
中科院分区：
文献类型：
--
作者：
HIRANO, T;MATSUDA, T;KISHIMOTO, T
重组B细胞刺激因子2 （rBSF-2）在人二倍体成纤维细胞、DIP-2、FS-4、FS-7、羊膜源性WISH和FL细胞感染水疱性口炎病毒（VSV）和Sindbis病毒（< 2.5倍）时未显示出任何可检测的抗病毒活性。102 IU /毫克)。此外anti-IFN度量。不能中和BSF-2的免疫球蛋白诱导活性。此外，抗bsf -2不能中和IFN- β的抗病毒活性。这些数据表明BSF-2在功能和免疫上与ifn无关。
Recombinant B cell stimulatory factor 2 (rBSF-2) did not display any detectable level of antiviral activity when using human diploid fibroblasts, DIP-2, FS-4, FS-7, amnion-derived WISH and FL cells with vesicular stomatitis virus (VSV) and Sindbis virus as challenging agents (< 2.5 .times. 102 IU/mg). Furthermore anti-IFN-.beta. could not neutralize the immunoglobulin-inducing activity of BSF-2. Moreover anti-BSF-2 could not neutralize the antiviral activity of IFN-.beta.. The data indicate that BSF-2 is functionally and immunologically not related to IFNs.