Expression of TGF-βs in the embryonic nervous system:: Analysis of interbalance between isoforms
Expression of TGF-βs in the embryonic nervous system:: Analysis of interbalance between isoforms
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DOI：
10.1002/dvdy.21558
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发表时间：
2008-06-01
影响因子：
2.5
通讯作者：
Blanco, M. J.
中科院分区：
文献类型：
--
作者：
Mecha, M.;Rabadan, M. A.;Blanco, M. J.
转化生长因子- β (tgf - β)是一类在胚胎发育过程中发挥重要作用的生长因子。在哺乳动物中，有三种同种异构体（tgf - β 1, tgf - β 2, tgf - β 3）被描述。在神经系统中，除了脑膜和脉络膜丛外，tgf - β 1在其他结构中仍未被检测到，而tgf - β 2和tgf - β 3被认为是该家族的神经成员。在本研究中，我们分析了这三种亚型在小鼠和鸡的神经管、脑和脊髓发育过程中的表达模式。数据揭示了每种异构体的特定模式。这项工作还表明tgf - β 1和tgf - β 3在神经嵴细胞中表达。此外，我们证明了tgf - β 1和tgf - β 3之间存在可能具有功能意义的平衡，这与tgf - β 1在中枢神经系统中的表达一起，是本工作最重要的贡献之一。
Transforming growth factor-beta (TGF-beta) is a family of growth factors with essential and multiple roles during embryonic development. In mammals, three isoforms (TGF-beta 1, TGF-beta 2, TGF-beta 3) have been described. In the, nervous system, the presence of TGF-beta 1 has remained undetectable in other structures than meninges and choroids plexus, while TGF-beta 2 and TGF-beta 3 were considered as the neural members of the family. In the present study, we have analysed the expression pattern of the three isoforms in the neural tube, brain, and spinal cord during development in both mouse and chicken. The data reveal specific patterns for each isoform. This work also shows that both TGF-beta 1 and TGF-beta 3 are expressed in neural crest cells. In addition, we demonstrate the existence of interbalance between TGF-beta 1 and TGF-beta 3 with possible functional implications, which, together with the expression of TGF-beta 1 in the CNS, represents one of the most important contributions of this work.