New microwave thermokeratoplasty and accelerated crosslinking method for keratoconus: Results in 24 eyes during a 1-year follow-up
New microwave thermokeratoplasty and accelerated crosslinking method for keratoconus: Results in 24 eyes during a 1-year follow-up
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DOI：
10.1016/j.jcrs.2014.06.028
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发表时间：
2015-02-01
影响因子：
2.8
通讯作者：
Yilmaz, Omer Faruk
中科院分区：
文献类型：
--
作者：
Celik, Ugur;Alagoz, Nese;Yilmaz, Omer Faruk
目得：目的：评价微波角膜热成形术联合加速角膜胶原交联（CXL）治疗圆锥角膜患者的安全性和有效性。单位：土耳其伊斯坦布尔市角膜屈光外科。设计：前瞻性临床试验。主要结果措施的变化logMAR未矫正（UDVA）和矫正（CDVA）远视力和角膜曲率（K）value.RESULTS：该研究纳入了24例患者的24只眼，年龄在18至45岁。尝试的矫正范围为-1.60至-6.50屈光度（D）。平均术前UDVA为0.66 logMAR +/- 0.26（SD），术后1个月显著改善至0.39 +/- 0.21 logMAR。然而，到6个月时，平均UDVA回归至0.58 +/- 0.21 logMAR。12个月时，平均UDVA为0.62 +/- 0.17 logMAR。术前平均K值为49.11 +/- 2.43 D，术后1个月为43.50 +/- 3.04 D，6个月为47.52 +/- 2.99 D，12个月为48.37 +/- 3.00 D。有没有显着的内皮细胞损失或损失的CDVA线在12 months.Conclusions：新的thermokeratoplasty程序，然后加速CXL产生所需的K值减少和改善术后UDVA没有显着的副作用。然而，热角膜移植术效果的早期和完全消退表明需要进一步发展这项技术。
PURPOSE: To evaluate the safety and efficacy of a new microwave thermokeratoplasty procedure combined with accelerated corneal collagen crosslinking (CXL) to improve visual function in patients with keratoconus.SETTING: Cornea and refractive surgery department, Istanbul, Turkey.DESIGN: Prospective clinical trial.METHODS: Patients with keratoconus who had the combined procedure were evaluated over 12 months postoperatively. The main outcome measures were changes in logMAR uncorrected (UDVA) and corrected (CDVA) distance visual acuities and in keratometry (K) values.RESULTS: The study enrolled 24 eyes of 24 patients aged 18 to 45 years. The attempted corrections ranged from -1.60 to -6.50 diopters (D). The mean preoperative UDVA of 0.66 logMAR +/- 0.26 (SD) significantly improved to 0.39 +/- 0.21 logMAR 1 month postoperatively. However by 6 months, the mean UDVA had regressed to 0.58 +/- 0.21 logMAR. At 12 months, the mean UDVA was 0.62 +/- 0.17 logMAR. The mean K value was 49.11 +/- 2.43 D preoperatively, 43.50 +/- 3.04 D 1 month postoperatively, 47.52 +/- 2.99 D at 6 months, and 48.37 +/- 3.00 D at 12 months. There were no cases of significant endothelial cell loss or loss of CDVA lines at 12 months.CONCLUSIONS: The new thermokeratoplasty procedure followed by accelerated CXL produced the desired reduction in K values and improvement in postoperative UDVA without significant side effects. However, the early and complete regression of the thermokeratoplasty effect shows the need for further advancement of this technology.