The influence of age, sex, and race on the incidence of esophageal cancer in the United States (1992--2006)
The influence of age, sex, and race on the incidence of esophageal cancer in the United States (1992--2006)
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DOI：
10.3109/00365521.2011.551890
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发表时间：
2011-05-01
影响因子：
1.9
通讯作者：
El-Serag, Hashem
中科院分区：
文献类型：
--
作者：
Nordenstedt, Helena;El-Serag, Hashem
背景食管癌患者中男性占显著优势。性激素被认为是一个促成因素，这些因素受年龄和种族的影响。在这项研究中，我们研究了美国食管癌的男女发病率比率。方法.我们使用来自监测、流行病学和最终结果（SEER）数据库中13个登记处的数据，计算1992- 2006年期间不同年龄和种族组中诊断的食管腺癌（EA）和食管鳞状细胞癌（ESCC）的男女发病率比。结果对于EA，所有种族具有相似的性别和年龄特异性发病率模式，显示50- 59岁年龄组的男性与女性发病率比率达到峰值，此后随年龄下降。西班牙裔男女比例最高（20.5），黑人最低（7.0），白人为10.8。相比之下，在ESCC的不同年龄组中，男性与女性的发病率比率较低且相当稳定。结论食管癌的男女发病率比根据组织学、年龄和种族而有很大差异。在50- 59岁年龄组中，EA的性别比例最高，这与女性性激素暴露可能在这种癌症的发展中起保护作用的假设相一致。
Background. There is a striking male predominance in esophageal cancer patients. Sex hormones have been suggested as a contributing factor and these are influenced by age and race. In this study, we examined the male-to-female incidence rate ratios of esophageal cancer in the United States. Methods. We used data from 13 registries in the Surveillance, Epidemiology, and End Results (SEER) database to calculate male-to-female incidence rate ratios of esophageal adenocarcinoma (EA) and esophageal squamous cell carcinoma (ESCC) diagnosed during 1992--2006 in different age and race groups. Results. For EA, all races had similar sex and age-specific incidence patterns showing a peak in the male-to-female incidence rate ratio in the age group 50--59, and an age-related decline thereafter. The highest male-to-female ratio was seen in Hispanics (20.5) and the lowest in Blacks (7.0) compared with 10.8 in Whites. By contrast, the male-to-female incidence rate ratios were low and fairly stable throughout the different age groups in ESCC. Conclusion. The male-to-female incidence rate ratios in esophageal cancer vary considerably according to histology, age, and race. The highest sex ratios were seen in EA in the age group 50--59, rendering plausibility to the hypothesis that female sex hormone exposure may play a protective role in the development of this cancer.